Query author contributions in Reactome
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Details on Person Later ZAP-70 undergoes trans-autophosphorylation at Y315 and...
| Class:Id | Summation:203253 |
|---|---|
| _displayName | Later ZAP-70 undergoes trans-autophosphorylation at Y315 and... |
| _timestamp | 2007-11-16 10:40:51 |
| created | [InstanceEdit:203257] Garapati, P V, 2007-11-12 15:37:54 |
| literatureReference | [LiteratureReference:202592] Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation |
| modified | [InstanceEdit:203778] Garapati, P V, 2007-11-16 10:40:11 |
| text | Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319. These sites appear to be positive regulatory sites. ZAP-70 achieve its full activation after the trans-autophosphorylation. Activated ZAP-70 phosphorylates T-cell-specific adaptors, such as LAT and SLP-76 leading to the recruitment and activation of other kinase families and enzymes, resulting in secondary messenger generation and culminating in T cell activation. |
| (summation) | [Reaction:202174] Activation of ZAP-70 [Homo sapiens] |
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No pathways have been reviewed or authored by Later ZAP-70 undergoes trans-autophosphorylation at Y315 and... (203253)
