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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of Cytosolic sensors of pathogen-associated DNA

Class:IdPathwayDiagram:2032400
_displayNameDiagram of Cytosolic sensors of pathogen-associated DNA
_timestamp2022-03-01 17:37:46
created[InstanceEdit:2032399] Shamovsky, V, 2012-01-06
height1637
modified[InstanceEdit:2054085] Shamovsky, V, 2012-01-12
[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
[InstanceEdit:2408498] Shamovsky, V, 2012-07-17
[InstanceEdit:2408563] Shamovsky, V, 2012-07-17
[InstanceEdit:2422453] Shamovsky, V, 2012-07-19
[InstanceEdit:3222295] Shamovsky, V, 2013-03-18
[InstanceEdit:3222334] Shamovsky, V, 2013-03-19
[InstanceEdit:3244664] Shamovsky, V, 2013-03-28
[InstanceEdit:3245944] Shamovsky, V, 2013-03-28
[InstanceEdit:3248025] Shamovsky, V, 2013-04-05
[InstanceEdit:3249352] Shamovsky, V, 2013-04-08
[InstanceEdit:3261244] Shamovsky, V, 2013-04-10
[InstanceEdit:3270621] Shamovsky, V, 2013-04-11
[InstanceEdit:3465599] Shamovsky, V, 2013-05-17
[InstanceEdit:3508880] Shamovsky, V, 2013-05-19
[InstanceEdit:3543165] Shamovsky, V, 2013-05-20
[InstanceEdit:3558425] Shamovsky, V, 2013-05-20
[InstanceEdit:3604386] Shamovsky, V, 2013-05-23
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8862416] Jupe, Steve, 2016-02-26
[InstanceEdit:8948739] Shamovsky, Veronica, 2016-11-15
[InstanceEdit:9014387] Shamovsky, Veronica, 2017-07-28
[InstanceEdit:9014549] Shamovsky, Veronica, 2017-08-01
[InstanceEdit:9014555] Shamovsky, Veronica, 2017-08-01
[InstanceEdit:9015696] Shamovsky, Veronica, 2017-08-11
[InstanceEdit:9029371] Jupe, Steve, 2017-11-16
[InstanceEdit:9604485] Shamovsky, Veronica, 2018-04-03
[InstanceEdit:9604493] Shamovsky, Veronica, 2018-04-03
[InstanceEdit:9628334] Shamovsky, Veronica, 2018-11-08
[InstanceEdit:9644459] Matthews, Lisa, 2019-04-14
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9691185] Jassal, Bijay, 2020-06-09
[InstanceEdit:9696611] Jassal, Bijay, 2020-07-23
[InstanceEdit:9716664] Shamovsky, Veronica, 2021-02-23
[InstanceEdit:9750223] Shamovsky, Veronica, 2021-08-11
[InstanceEdit:9763815] D'Eustachio, Peter, 2022-02-04
[InstanceEdit:9764692] Shamovsky, Veronica, 2022-02-14
[InstanceEdit:9767734] Shamovsky, Veronica, 2022-03-01
[InstanceEdit:9767778] Shamovsky, Veronica, 2022-03-01
representedPathway[Pathway:1834949] Cytosolic sensors of pathogen-associated DNA [Homo sapiens]
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</Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableCompartment id="3436" reactomeId="17940" position="661 1334" bounds="576 1304 170 61" textPosition="596 1322" bgColor="250 240 240" lineColor="255 153 102" insets="585 1312 151 46"> <Properties> <displayName>endosome</displayName> </Properties> <Components> <Component id="3434" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemicalDrug id="3726" reactomeId="9679801" position="685 903" bounds="645 888 80 31" textPosition="649 892" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>amlexanox</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="3727" reactomeId="9679814" position="786 952" bounds="733 941 107 23" textPosition="733 942" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>TBK1:amlexanox</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3730" reactomeId="874111" position="383 584" bounds="364 573 38 23" textPosition="364 573"> <Properties> <displayName>AIM2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3731" reactomeId="874096" position="573 567" bounds="532 556 82 23" textPosition="532 557" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>dsDNA:AIM2</displayName> </Properties> <OldBounds> <Bounds id="3731" bounds="496 545 161 70" /> </OldBounds> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3736" reactomeId="166059" position="315 1372" bounds="290 1361 51 23" textPosition="290 1361"> <Properties> <displayName>MYD88</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="3739" reactomeId="168643" position="528 648" bounds="432 606 193 84" textPosition="434 612"> <Properties> <displayName>Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways</displayName> </Properties> </org.gk.render.ProcessNode> </Nodes> <Edges> <org.gk.render.RenderableReaction id="141" reactomeId="1591234" points="359 708, 386 709, 417 718" position="386 709" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3405" points="336 690" /> <Input id="143" stoichiometry="2" points="334 715" /> </Inputs> <Outputs> <Output id="144" /> </Outputs> <Properties> <displayName>ZBP1 binds cytosolic DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="1606324" points="519 903, 555 903, 590 903" position="555 903" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="147" stoichiometry="2" points="492 886" /> <Input id="144" points="453 747" /> <Input id="148" stoichiometry="2" points="486 923" /> </Inputs> <Outputs> <Output id="149" points="624 978" /> <Output id="150" stoichiometry="2" points="602 840" /> </Outputs> <Properties> <displayName>Recruitment TBK1 to dsDNA:ZBP1 followed by its activation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="151" reactomeId="1810457" points="491 1116, 527 1117, 581 1117" position="527 1117" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="152" points="454 1133" /> <Input id="144" points="446 747, 382 1023" /> <Input id="153" points="454 1114" /> </Inputs> <Outputs> <Output id="154" /> </Outputs> <Properties> <displayName>ZBP1(DAI) recruits RIP1 and RIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="1606345" points="743 998, 771 998, 808 998" position="771 998" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="149" points="690 998" /> <Input id="156" stoichiometry="2" points="715 1024" /> </Inputs> <Outputs> <Output id="157" /> </Outputs> <Inhibitors> <Inhibitor id="3727" points="782 967" /> </Inhibitors> <Properties> <displayName>Recruitment of IRF3 to activated ZBP1:TBK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="1606327" points="1012 999, 1047 998, 1074 999" position="1047 998" lineWidth="1.0"> <Inputs> <Input id="157" points="921 999" /> <Input id="159" stoichiometry="10" points="982 1017" /> </Inputs> <Outputs> <Output id="311" stoichiometry="2" points="1195 939" /> <Output id="149" points="632 1021, 631 1068, 1093 1069" /> <Output id="310" stoichiometry="10" points="1109 1012" /> </Outputs> <Inhibitors> <Inhibitor id="2755" points="881 880, 1047 971" /> </Inhibitors> <Properties> <displayName>Phosphorylation and release of IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="168910" points="614 1236, 635 1236, 655 1236" position="635 1236" lineWidth="1.0"> <Inputs> <Input id="168" points="591 1251" /> <Input id="169" points="569 1230" /> </Inputs> <Outputs> <Output id="170" points="687 1255" /> <Output id="171" points="749 1186" /> </Outputs> <Activators> <Activator id="154" points="641 1139, 641 1213" /> <Activator id="3434" points="638 1290" /> </Activators> <Properties> <displayName>RIP1 facilitates IKK complex phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="172" reactomeId="168140" points="911 1128, 911 1158, 911 1186" position="911 1158" lineWidth="1.0"> <Inputs> <Input id="173" points="892 1117" /> <Input id="174" stoichiometry="4" points="942 1108" /> </Inputs> <Outputs> <Output id="175" points="964 1203" /> <Output id="176" stoichiometry="4" points="917 1227" /> <Output id="177" points="849 1217" /> </Outputs> <Catalysts> <Catalyst id="171" points="854 1157, 883 1157" /> </Catalysts> <Inhibitors> <Inhibitor id="3435" points="946 1158" /> </Inhibitors> <Properties> <displayName>Active IKK Complex phosphorylates NF-kappa-B inhibitor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="275" reactomeId="2032396" points="1150 1197, 1153 1376, 1153 1407" position="1153 1376" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="276" /> </Inputs> <Outputs> <Output id="283" /> </Outputs> <Properties> <displayName>Dimerized phospho-IRF3 migrates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="317" reactomeId="1834951" points="324 308, 351 309, 392 321" position="351 309" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3325" points="296 307" /> <Input id="318" points="302 337" /> </Inputs> <Outputs> <Output id="319" /> </Outputs> <Properties> <displayName>IFI16 binds cytosolic dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="321" reactomeId="2396009" points="882 330, 882 352, 781 446" position="882 352" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="322" points="760 309" /> <Input id="323" points="1009 254" /> </Inputs> <Outputs> <Output id="324" /> </Outputs> <Properties> <displayName>STING binds c-di-GMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="326" reactomeId="1834939" points="1011 408, 980 409, 949 455" position="980 409" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1680" points="1097 455" /> <Input id="554" stoichiometry="2" points="1022 404" /> <Input id="2877" stoichiometry="2" points="1087 415" /> </Inputs> <Outputs> <Output id="327" /> </Outputs> <Inhibitors> <Inhibitor id="1387" points="1127 250, 975 384" /> <Inhibitor id="3271" points="1052 366" /> </Inhibitors> <Activators> <Activator id="373" points="631 246, 658 349" /> <Activator id="1184" points="580 514, 619 376" /> <Activator id="319" points="470 340" /> <Activator id="374" points="521 406, 588 365" /> <Activator id="3428" points="572 294, 595 348" /> <Activator id="324" points="765 446, 745 401" /> <Activator id="1168" points="736 496, 635 388" /> </Activators> <Properties> <displayName>STING recruits TBK1 and IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="331" reactomeId="2396002" points="726 556, 727 574, 726 593" position="727 574" lineWidth="1.0"> <Inputs> <Input id="332" stoichiometry="2" points="703 548" /> <Input id="327" points="911 484, 740 546" /> </Inputs> <Outputs> <Output id="333" points="749 601" /> <Output id="334" stoichiometry="2" points="704 605" /> </Outputs> <Properties> <displayName>TBK1 is phosphorylated within STING:TBK1:IRF3 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="335" reactomeId="2396007" points="860 646, 886 645, 906 645" position="886 645" lineWidth="1.0"> <Inputs> <Input id="333" points="844 639" /> <Input id="336" stoichiometry="10" points="836 663" /> </Inputs> <Outputs> <Output id="337" points="943 627" /> <Output id="354" stoichiometry="10" points="966 657" /> <Output id="311" stoichiometry="2" points="1204 910" /> </Outputs> <Catalysts> <Catalyst id="333" points="844 628, 867 632" /> </Catalysts> <Inhibitors> <Inhibitor id="3272" points="1105 586, 1104 582, 885 582" /> </Inhibitors> <Properties> <displayName>IRF3 is phosphorylated by TBK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="370" reactomeId="2395992" points="1216 939, 1216 1039, 1158 1154" position="1216 1039" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="311" stoichiometry="2" /> </Inputs> <Outputs> <Output id="276" /> </Outputs> <Properties> <displayName>p-T,4S-IRF3 is dimerized</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="375" reactomeId="3134822" points="372 222, 435 222, 574 223" position="435 222" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3433" points="281 222" /> <Input id="379" points="283 150" /> </Inputs> <Outputs> <Output id="373" /> </Outputs> <Inhibitors> <Inhibitor id="380" points="418 192, 435 207" /> </Inhibitors> <Properties> <displayName>DDX41 binds viral dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="382" reactomeId="3134821" points="374 427, 398 427, 431 427" position="398 427" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="383" points="351 411" /> <Input id="384" points="355 434" /> <Input id="3328" points="297 419" /> </Inputs> <Outputs> <Output id="374" /> </Outputs> <Properties> <displayName>DNA-PK binds microbial dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="393" reactomeId="3134800" points="985 130, 970 187, 1015 225" position="970 187" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1722" stoichiometry="2" /> </Inputs> <Outputs> <Output id="323" /> </Outputs> <Activators> <Activator id="1602" points="1338 131, 995 187" /> </Activators> <Properties> <displayName>STING dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="394" reactomeId="3134896" points="166 631, 194 630, 194 720" position="194 630" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="395" points="138 645" /> <Input id="3330" points="140 621" /> </Inputs> <Outputs> <Output id="396" /> </Outputs> <Properties> <displayName>LRR FLII-interacting protein 1 binds dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="558" reactomeId="3134901" points="271 809, 271 831, 272 870" position="271 831" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="396" points="226 777" /> <Input id="559" points="297 788" /> </Inputs> <Outputs> <Output id="560" /> </Outputs> <Properties> <displayName>LRR FLII-interacting protein 1 associates with beta-catenin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="561" reactomeId="3134904" points="273 981, 272 1008, 272 1033" position="272 1008" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="562" points="319 951" /> <Input id="560" points="273 913" /> </Inputs> <Outputs> <Output id="396" points="193 777, 189 1063" /> <Output id="563" points="319 1051" /> <Output id="564" points="275 1088" /> </Outputs> <Properties> <displayName>Phosphorylation of beta-catenin at Ser552</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="565" reactomeId="3134914" points="285 1117, 505 1377, 832 1500" position="505 1377" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="564" /> </Inputs> <Outputs> <Output id="566" /> </Outputs> <Properties> <displayName>Beta-catenin migrates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="568" reactomeId="3134883" points="1153 1516, 1212 1515, 1250 1545" position="1212 1515" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="569" points="1109 1534" /> <Input id="283" points="1153 1450" /> <Input id="570" points="1093 1498" /> <Input id="566" points="921 1514" /> </Inputs> <Outputs> <Output id="571" /> </Outputs> <Properties> <displayName>Beta-catenin enhances association of IRF3 with CBP/p300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="573" reactomeId="3134962" points="209 1240, 240 1240, 264 1242" position="240 1240" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="574" points="162 1282" /> <Input id="575" points="175 1236" /> </Inputs> <Outputs> <Output id="576" /> </Outputs> <Properties> <displayName>DHX36 binds DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="577" reactomeId="3134954" points="209 1218, 240 1218, 267 1214" position="240 1218" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="578" points="161 1181" /> <Input id="575" points="175 1223" /> </Inputs> <Outputs> <Output id="579" /> </Outputs> <Properties> <displayName>DHX9 binds DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="581" reactomeId="3134953" points="401 1377, 401 1410, 401 1433" position="401 1410" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="582" points="370 1339" /> <Input id="3736" stoichiometry="2" points="344 1373" /> </Inputs> <Outputs> <Output id="586" /> </Outputs> <Properties> <displayName>DHX36 or DHX9 binds MyD88</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="583" points="345 1220, 354 1224, 361 1304" position="354 1224" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="579" /> </Inputs> <Outputs> <Output id="582" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="584" points="316 1261, 353 1304" position="334 1282" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="576" /> </Inputs> <Outputs> <Output id="582" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="587" points="844 1371, 815 1370, 469 1443" position="815 1370" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="372" /> </Inputs> <Outputs> <Output id="586" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="592" points="405 1505, 402 1482" position="403 1493" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="591" /> </Inputs> <Outputs> <Output id="586" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="610" reactomeId="3134946" points="434 135, 463 135, 508 135" position="463 135" lineWidth="1.0"> <Inputs> <Input id="379" points="299 135" /> <Input id="380" points="415 163" /> <Input id="2854" stoichiometry="3" points="399 117" /> </Inputs> <Outputs> <Output id="611" /> </Outputs> <Catalysts> <Catalyst id="380" points="439 166, 461 157" /> </Catalysts> <Properties> <displayName>DDX41 ubiquitination by TRIM21</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1154" reactomeId="3244647" points="210 84, 260 84, 623 84" position="260 84" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1160" points="176 67" /> <Input id="3331" points="166 99" /> </Inputs> <Outputs> <Output id="1161" /> </Outputs> <Properties> <displayName>cGAS binds cytosolic DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1162" reactomeId="3244614" points="834 133, 835 163, 836 200" position="835 163" lineWidth="1.0"> <Inputs> <Input id="1163" points="807 101" /> <Input id="1164" points="859 105" /> </Inputs> <Outputs> <Output id="1165" points="813 255" /> <Output id="1166" stoichiometry="2" points="871 230" /> </Outputs> <Catalysts> <Catalyst id="1161" points="687 99, 807 161" /> </Catalysts> <Properties> <displayName>cGAS produces cyclic GMP-AMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1167" reactomeId="3244643" points="944 323, 945 358, 815 487, 781 496" position="945 358" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1165" points="850 292" /> <Input id="323" points="1016 254" /> </Inputs> <Outputs> <Output id="1168" /> </Outputs> <Properties> <displayName>STING binds cyclic GMP-AMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1385" reactomeId="3244605" points="1273 266, 1304 264, 1324 248" position="1304 264" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1387" points="1186 245" /> <Input id="1741" stoichiometry="4" points="1207 287" /> <Input id="1386" stoichiometry="2" points="1274 302" /> </Inputs> <Outputs> <Output id="1388" /> </Outputs> <Properties> <displayName>TREX1 binds retroviral-derived DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1415" reactomeId="3245943" points="1379 296, 1380 329, 1382 367" position="1380 329" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1388" points="1343 248" /> <Input id="1416" points="1400 279" /> </Inputs> <Outputs> <Output id="2900" points="1409 370" /> <Output id="1387" points="1140 250, 1141 349" /> <Output id="3270" points="1419 338" /> <Output id="2901" points="1443 428" /> <Output id="2899" points="1340 392" /> </Outputs> <Catalysts> <Catalyst id="1388" points="1338 248, 1355 329" /> </Catalysts> <Properties> <displayName>Viral DNA cleavage by TREX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1721" reactomeId="1964496" points="1017 86, 1073 85, 1140 103" position="1073 85" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1722" points="1000 101" /> <Input id="1723" points="998 73" /> </Inputs> <Outputs> <Output id="1724" /> </Outputs> <Properties> <displayName>STING binds TRIM32 or TRIM56</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1725" reactomeId="3134804" points="1293 87, 1317 88, 1342 87" position="1317 88" lineWidth="1.0"> <Inputs> <Input id="1726" stoichiometry="3" points="1244 69" /> <Input id="1724" points="1251 100" /> </Inputs> <Outputs> <Output id="1602" points="1379 108" /> <Output id="1723" points="1047 46, 1058 44, 1342 44" /> </Outputs> <Catalysts> <Catalyst id="1724" points="1251 115, 1318 113" /> </Catalysts> <Properties> <displayName>STING ubiquitination by TRIM32 or TRIM56</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2875" reactomeId="3249378" points="1190 437, 1214 436, 1271 458" position="1214 436" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1680" points="1143 455" /> <Input id="2872" stoichiometry="2" points="1171 409" /> <Input id="2877" stoichiometry="2" points="1133 422" /> </Inputs> <Outputs> <Output id="2873" /> </Outputs> <Properties> <displayName>STING recruits TBK1 and STAT6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2879" reactomeId="3249390" points="1364 498, 1365 518, 1365 536" position="1365 518" lineWidth="1.0"> <Inputs> <Input id="2873" points="1327 487" /> <Input id="2880" stoichiometry="2" points="1392 498" /> </Inputs> <Outputs> <Output id="2881" points="1367 556" /> <Output id="2882" stoichiometry="2" points="1396 536" /> </Outputs> <Properties> <displayName>TBK1 is phosphorylated within STING:TBK1:STAT6 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2884" reactomeId="3249371" points="1372 625, 1373 650, 1374 666" position="1373 650" lineWidth="1.0"> <Inputs> <Input id="2885" stoichiometry="2" points="1406 626" /> <Input id="2881" points="1370 599" /> </Inputs> <Outputs> <Output id="337" points="965 598, 968 568, 1293 567, 1344 697" /> <Output id="2886" stoichiometry="2" points="1378 717" /> <Output id="2887" stoichiometry="2" points="1412 670" /> </Outputs> <Catalysts> <Catalyst id="2881" points="1361 599, 1348 631" /> </Catalysts> <Properties> <displayName>TBK1 phosphorylates STAT6 at Ser407</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2889" reactomeId="3249379" points="1380 761, 1380 787, 1381 810" position="1380 787" lineWidth="1.0"> <Inputs> <Input id="2890" points="1404 763" /> <Input id="2886" points="1379 746" /> </Inputs> <Outputs> <Output id="2891" points="1382 851" /> <Output id="2892" points="1404 812" /> </Outputs> <Properties> <displayName>p-S407-STAT6 is phosphorylated at Tyr641</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2894" reactomeId="3249372" points="1383 894, 1383 1037, 1339 1148" position="1383 1037" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2891" stoichiometry="2" /> </Inputs> <Outputs> <Output id="2895" /> </Outputs> <Properties> <displayName>p-S407,Y641-STAT6 is dimerized</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2896" reactomeId="3249370" points="1332 1191, 1335 1373, 1304 1408" position="1335 1373" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2895" /> </Inputs> <Outputs> <Output id="2897" /> </Outputs> <Properties> <displayName>p-S407,Y641-STAT6 dimer migrates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3015" reactomeId="3204303" points="459 526, 486 527, 527 527" position="486 527" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3016" points="419 537" /> <Input id="3335" points="451 514" /> </Inputs> <Outputs> <Output id="1184" /> </Outputs> <Properties> <displayName>MRE11 binds cytosolic DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3031" reactomeId="3249386" points="892 767, 915 767, 943 767, 980 763" position="915 767" lineWidth="1.0"> <Inputs> <Input id="2755" points="853 823" /> <Input id="3034" stoichiometry="3" points="868 747" /> </Inputs> <Outputs> <Output id="3273" points="989 790" /> <Output id="3323" points="1161 710" /> <Output id="3321" points="1229 727" /> </Outputs> <Catalysts> <Catalyst id="2755" points="868 823, 914 789" /> </Catalysts> <Properties> <displayName>DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3036" reactomeId="1964482" points="143 1462, 178 1462, 212 1462" position="178 1462" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3412" /> </Inputs> <Outputs> <Output id="3043" /> </Outputs> <Catalysts> <Catalyst id="3044" points="177 1423" /> </Catalysts> <Properties> <displayName>RNA polymerase III transcribes microbial dsDNA to dsRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3269" interactionType="Activate" points="242 1485, 179 1527" position="210 1506" lineWidth="2.0"> <Inputs> <Input id="3043" /> </Inputs> <Outputs> <Output id="3264" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="3274" reactomeId="8948703" points="686 854, 729 851, 781 851" position="729 851" lineWidth="1.0"> <Inputs> <Input id="3027" points="612 736" /> <Input id="3026" points="667 765" /> <Input id="149" points="633 978, 633 893" /> </Inputs> <Outputs> <Output id="2755" /> </Outputs> <Properties> <displayName>NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3275" reactomeId="8948709" points="1144 667, 1163 665, 1190 666" position="1163 665" lineWidth="1.0"> <Inputs> <Input id="3272" points="1119 629" /> <Input id="3278" stoichiometry="3" points="1126 686" /> </Inputs> <Outputs> <Output id="3276" points="1213 651" /> <Output id="3321" points="1242 710" /> <Output id="3323" points="1186 690" /> </Outputs> <Catalysts> <Catalyst id="3272" points="1125 629" /> </Catalysts> <Properties> <displayName>DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3324" reactomeId="3249392" points="789 717, 897 717, 1062 718, 1100 629" position="897 717" lineWidth="1.0"> <Inputs> <Input id="3027" points="633 720" /> <Input id="3026" points="689 744" /> <Input id="333" points="790 644" /> </Inputs> <Outputs> <Output id="3272" /> </Outputs> <Properties> <displayName>NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3424" reactomeId="9013869" points="348 271, 471 271, 503 271" position="471 271" lineWidth="1.0"> <Inputs> <Input id="3425" points="301 271" /> <Input id="379" points="276 150" /> </Inputs> <Outputs> <Output id="3428" /> </Outputs> <Properties> <displayName>DDX41 binds bacterial c-di-AMP, c-di-GMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3655" reactomeId="9604480" points="1015 1246, 1015 1375, 1015 1417" position="1015 1375" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="175" /> </Inputs> <Outputs> <Output id="188" /> </Outputs> <Activators> <Activator id="372" points="967 1374" /> </Activators> <Properties> <displayName>NFkB complex translocates from the cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3703" reactomeId="9604487" points="453 1576, 509 1578, 569 1578" position="509 1578" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="589" /> </Inputs> <Outputs> <Output id="590" /> </Outputs> <Activators> <Activator id="591" points="438 1534, 508 1556" /> </Activators> <Properties> <displayName>p-IRF7:p-IRF7 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3725" reactomeId="9679819" points="700 953, 699 952, 730 952" position="699 952" lineWidth="1.0"> <Inputs> <Input id="149" points="659 978" /> <Input id="3726" points="689 922" /> </Inputs> <Outputs> <Output id="3727" /> </Outputs> <Properties> <displayName>TBK1 binds amlexanox</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3729" reactomeId="844619" points="458 555, 494 555, 529 560" position="494 555" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3730" points="405 576" /> <Input id="3335" points="446 514" /> </Inputs> <Outputs> <Output id="3731" /> </Outputs> <Properties> <displayName>AIM2 binds dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3741" interactionType="Activate" points="566 582, 552 603" position="559 592" lineWidth="2.0"> <Inputs> <Input id="3731" /> </Inputs> <Outputs> <Output id="3739" /> </Outputs> <Properties> <displayName>dsDNA:AIM2 Activates Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Cytosolic sensors of pathogen-associated DNA (2032400)
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