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Details on Person Autocatalytic phosphorylation of FGFR2 ligand-independent mutants

Class:IdReaction:2029984
_displayNameAutocatalytic phosphorylation of FGFR2 ligand-independent mutants
_doReleaseTRUE
_timestamp2015-05-07 19:53:51
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity[CatalystActivity:2029972] protein tyrosine kinase activity of FGFR2 ligand-independent mutant dimers [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:2029982] Rothfels, K, 2012-01-05
disease[Disease:1500689] cancer
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5654449] gain_of_function of FGFR2 ligand-independent mutant dimers [plasma membrane]
input[CandidateSet:2029952] FGFR2 ligand-independent mutant dimers [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:2029801] Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand
[LiteratureReference:2038356] Stop codon FGFR3 mutations in thanatophoric dwarfism type 1
[LiteratureReference:2018765] Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
[LiteratureReference:2060748] Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization
[LiteratureReference:2032923] Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras
[LiteratureReference:2045070] Ligand-independent activation of fibroblast growth factor receptors by point mutations in the extracellular, transmembrane, and kinase domains
[LiteratureReference:2054054] Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
modified[InstanceEdit:2033508] Rothfels, K, 2012-01-09
[InstanceEdit:2060781] Rothfels, K, 2012-01-16
[InstanceEdit:2085559] Rothfels, K, 2012-02-03
[InstanceEdit:2105592] Rothfels, K, 2012-02-10
[InstanceEdit:2123522] Rothfels, K, 2012-02-14
[InstanceEdit:2156361] Rothfels, K, 2012-02-28
[InstanceEdit:2248846] Rothfels, K, 2012-05-15
[InstanceEdit:2275109] Rothfels, K, 2012-05-25
[InstanceEdit:5654450] Rothfels, Karen, 2014-12-03
[InstanceEdit:5691454] Rothfels, Karen, 2015-05-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAutocatalytic phosphorylation of FGFR2 ligand-independent mutants
output[CandidateSet:2029948] Activated FGFR2 ligand-independent mutants [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294800] R-HSA-2029984.2
summation[Summation:2060749] FGFR2 S267P undergoes ligand-independent dimerization, and a...
(hasEvent)[Pathway:2033519] Activated point mutants of FGFR2 [Homo sapiens]
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