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Details on Person p-8Y-FGFR2b S376C [plasma membrane]

Class:Id	EntityWithAccessionedSequence:2029866
_displayName	p-8Y-FGFR2b S376C [plasma membrane]
_timestamp	2014-11-20 17:34:18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2029867] Rothfels, K, 2012-01-05
disease	[Disease:1614674] female reproductive endometrioid cancer [Disease:1500575] ovarian cancer
endCoordinate	822
hasModifiedResidue	[ModifiedResidue:190945] O4'-phospho-L-tyrosine at 467 [ModifiedResidue:190951] O4'-phospho-L-tyrosine at 587 [ModifiedResidue:190950] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:190947] O4'-phospho-L-tyrosine at 657 [ModifiedResidue:190409] O4'-phospho-L-tyrosine at 658 [ModifiedResidue:190948] O4'-phospho-L-tyrosine at 734 [ModifiedResidue:190949] O4'-phospho-L-tyrosine at 770 [ModifiedResidue:1307909] O4'-phospho-L-tyrosine at 780 [ReplacedResidue:1637932] L-tyrosine 376 replaced with L-cysteine
literatureReference	[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:2029807] FGFR2 mutations are rare across histologic subtypes of ovarian cancer [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
modified	[InstanceEdit:2071965] Rothfels, K, 2012-01-26 [InstanceEdit:3508354] Jupe, S, 2013-05-17 [InstanceEdit:5649617] Rothfels, Karen, 2014-11-20
name	p-8Y-FGFR2b S376C p-8Y-FGFR2-3 S376C
referenceEntity	[ReferenceIsoform:147298] UniProt:P21802-3 FGFR2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295731] R-HSA-2029866.1
startCoordinate	22
summation	[Summation:1637914] also Apert
(hasComponent)	[Complex:2029909] Activated FGFR2b S376C mutant [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9882583] Update Tracker - [EntityWithAccessionedSequence:2029866] p-8Y-FGFR2b S376C [plasma membrane] - v45:[modifyName] [_UpdateTracker:9890165] Update Tracker - [EntityWithAccessionedSequence:2029866] p-8Y-FGFR2b S376C [plasma membrane] - v52:[modifyName]
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No pathways have been reviewed or authored by p-8Y-FGFR2b S376C [plasma membrane] (2029866)