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Details on Person Recruitment of VAV1 to p-6Y-SYK

Class:Id	Reaction:2029458
_displayName	Recruitment of VAV1 to p-6Y-SYK
_doRelease	TRUE
_timestamp	2019-10-25 13:02:04
authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:2029450] Garapati, P V, 2012-01-04
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
input	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [DefinedSet:430172] VAV1,2,3 [cytosol] [Homo sapiens] [Complex:2029158] clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:437948] Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product [LiteratureReference:2028812] Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis
modified	[InstanceEdit:2054094] Garapati, P V, 2012-01-13 [InstanceEdit:2197699] Garapati, P V, 2012-04-13 [InstanceEdit:2248843] Garapati, P V, 2012-05-14 [InstanceEdit:2272655] Garapati, P V, 2012-05-25 [InstanceEdit:2429700] Garapati, P V, 2012-08-09 [InstanceEdit:2457636] Garapati, P V, 2012-08-27 [InstanceEdit:3132781] Garapati, P V, 2013-02-13 [InstanceEdit:9664534] Murillo, Julieth, 2019-10-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of VAV1 to p-6Y-SYK
output	[Complex:2029133] clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2029449] Phosphorylation of SYK by Src kinases [Homo sapiens] [Reaction:2029452] Recruitment of SYK to phosphorylated ITAMs [Homo sapiens] [Reaction:9664261] Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK [Homo sapiens] [Reaction:9664273] SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers [Homo sapiens]
releaseDate	2013-03-12
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200455] R-HSA-2029458.3
summation	[Summation:2028893] VAV family members are cytoplasmic guanine nucleotide exchan...
(hasEvent)	[Pathway:2029482] Regulation of actin dynamics for phagocytic cup formation [Homo sapiens]
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No pathways have been reviewed or authored by Recruitment of VAV1 to p-6Y-SYK (2029458)