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Details on Person Autophosphorylation of PAK1

Class:Id	Reaction:2029454
_displayName	Autophosphorylation of PAK1
_doRelease	TRUE
_timestamp	2019-11-06 11:47:08
authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
catalystActivity	[CatalystActivity:445074] protein serine/threonine kinase activity of PAK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643360] protein serine/threonine kinase activity of PAK1 [cytosol] The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2029450] Garapati, P V, 2012-01-04
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:8981921] Orlic-Milacic, Marija, 2017-03-15
input	[Complex:2029159] RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 [LiteratureReference:399908] The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
modified	[InstanceEdit:2248843] Garapati, P V, 2012-05-14 [InstanceEdit:2262745] Garapati, P V, 2012-05-20 [InstanceEdit:2272655] Garapati, P V, 2012-05-25 [InstanceEdit:2429700] Garapati, P V, 2012-08-09 [InstanceEdit:2457636] Garapati, P V, 2012-08-27 [InstanceEdit:3132781] Garapati, P V, 2013-02-13 [InstanceEdit:8981921] Orlic-Milacic, Marija, 2017-03-15 [InstanceEdit:8981925] Orlic-Milacic, Marija, 2017-03-15 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9666696] Murillo, Julieth, 2019-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of PAK1
output	[DefinedSet:389778] CDC42:GTP, RAC1:GTP [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:399819] p-S144,T423-PAK1 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2013-03-12
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200358] R-HSA-2029454.5
summation	[Summation:2028800] PAK1 needs autophosphorylation for complete activation. PAK1...
(hasEvent)	[Pathway:2029482] Regulation of actin dynamics for phagocytic cup formation [Homo sapiens]
(precedingEvent)	[Reaction:5668947] PAK1 phosphorylates myosin phosphatase [Homo sapiens] [Reaction:5668984] PAK1 or PAK2 phosphorylates MYLK [Homo sapiens] [Reaction:5669240] FLNA binds PAK1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780954] Update Tracker - [Reaction:2029454] Autophosphorylation of PAK1 - v61:[add_removeOutput]
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No pathways have been reviewed or authored by Autophosphorylation of PAK1 (2029454)