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Details on Person An unknown GEF exchanges GTP for GDP on CDC42:GDP

Class:IdBlackBoxEvent:2029445
_displayNameAn unknown GEF exchanges GTP for GDP on CDC42:GDP
_doReleaseTRUE
_timestamp2020-02-06 10:15:26
authored[InstanceEdit:434636] Jupe, S, 2009-09-02
catalystActivity[CatalystActivity:2029264] guanyl-nucleotide exchange factor activity of Unknown GEF [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:2029446] Garapati, P V, 2012-01-04
edited[InstanceEdit:2029483] Garapati, P V, 2012-01-04
input[Complex:418830] CDC42:GDP [cytosol] [Homo sapiens]
[SimpleEntity:29438] GTP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:2028873] A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis
[LiteratureReference:2028975] Fc receptor-mediated phagocytosis requires CDC42 and Rac1
modified[InstanceEdit:2248843] Garapati, P V, 2012-05-14
[InstanceEdit:2272655] Garapati, P V, 2012-05-25
[InstanceEdit:2429700] Garapati, P V, 2012-08-09
[InstanceEdit:2457636] Garapati, P V, 2012-08-27
[InstanceEdit:3132781] Garapati, P V, 2013-02-13
[InstanceEdit:9667219] Murillo, Julieth, 2019-11-08
[InstanceEdit:9670158] Murillo, Julieth, 2019-12-05
[InstanceEdit:9675994] Murillo, Julieth, 2020-02-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAn unknown GEF exchanges GTP for GDP on CDC42:GDP
output[Complex:182921] CDC42:GTP [plasma membrane] [Homo sapiens]
[SimpleEntity:29420] GDP [cytosol]
releaseDate2013-03-12
reviewed[InstanceEdit:2248842] Rosales, C, 2012-05-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200527] R-HSA-2029445.4
summation[Summation:2028900] FCGR mediated phagocytosis requires CDC42 to stimulate actin...
(hasEvent)[Pathway:2029482] Regulation of actin dynamics for phagocytic cup formation [Homo sapiens]
[Pathway:9664422] FCGR3A-mediated phagocytosis [Homo sapiens]
(precedingEvent)[Reaction:442586] Activation of WASP and N-WASP by CDC42 [Homo sapiens]
[Reaction:2029456] RAC1 and CDC42 activate PAK1 [Homo sapiens]
[Reaction:9670156] PtdIns(4,5)P2 binds WASP, N-WASP [Homo sapiens]
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No pathways have been reviewed or authored by An unknown GEF exchanges GTP for GDP on CDC42:GDP (2029445)