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Details on Person FCGR mediated phagocytosis requires CDC42 to stimulate actin...
| Class:Id | Summation:2028900 |
|---|---|
| _displayName | FCGR mediated phagocytosis requires CDC42 to stimulate actin... |
| _timestamp | 2012-04-13 23:15:27 |
| created | [InstanceEdit:2028831] Garapati, P V, 2012-01-04 |
| literatureReference | [LiteratureReference:2028786] Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis [LiteratureReference:2028873] A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis [LiteratureReference:2028836] Vav regulates activation of Rac but not Cdc42 during FcgammaR-mediated phagocytosis |
| modified | [InstanceEdit:2029488] Garapati, P V, 2012-01-04 [InstanceEdit:2130213] Garapati, P V, 2012-02-21 [InstanceEdit:2197716] Garapati, P V, 2012-04-13 |
| text | FCGR mediated phagocytosis requires CDC42 to stimulate actin polymerization, generating the force for phagocytic cup protrusion or pseudopod extension. CDC42 activation is restricted at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the phagocytic cup (Beemiller et al 2010). The mechanism behind the recruitment and activation of CDC42 during FCGR phagocytosis is unknown. VAV regulates the activation of RAC1 but not CDC42 and the GEF responsible for CDC42 activation during FCGR-mediated phagocytosis remains unidentified (Adam et al 2004, Patel et al 2002). |
| (summation) | [BlackBoxEvent:2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP [Homo sapiens] |
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No pathways have been reviewed or authored by FCGR mediated phagocytosis requires CDC42 to stimulate actin... (2028900)
