Query author contributions in Reactome
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Details on Person The cortical actin cytoskeletal network is lost during apopt...
| Class:Id | Summation:202889 |
|---|---|
| _displayName | The cortical actin cytoskeletal network is lost during apopt... |
| _timestamp | 2007-11-12 10:01:57 |
| created | [InstanceEdit:202894] Matthews, L, 2007-11-12 10:01:45 |
| literatureReference | [LiteratureReference:202851] Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells |
| text | The cortical actin cytoskeletal network is lost during apoptosis. During apoptosis, increased phosphorylation of the actin capping protein alpha-adducin leads to its dissociation from the cytoskeleton. The caspase-3-mediated cleavage cleavage of alpha adducin at Asp-Asp-Ser-Asp(633)-Ala prevents its reassociation (van de Water et al, 2000). |
| (summation) | [Reaction:201608] Caspase-mediated cleavage of alpha adducin [Homo sapiens] |
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No pathways have been reviewed or authored by The cortical actin cytoskeletal network is lost during apopt... (202889)
