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Details on Person Side branching is the most popular and well accepted model f...
| Class:Id | Summation:2028889 |
|---|---|
| _displayName | Side branching is the most popular and well accepted model f... |
| _timestamp | 2012-02-21 17:27:36 |
| created | [InstanceEdit:2028831] Garapati, P V, 2012-01-04 |
| literatureReference | [LiteratureReference:2028852] ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays [LiteratureReference:2028835] Regulation of actin assembly associated with protrusion and adhesion in cell migration [LiteratureReference:418750] Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex [LiteratureReference:2028869] The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments |
| modified | [InstanceEdit:2130213] Garapati, P V, 2012-02-21 |
| text | Side branching is the most popular and well accepted model for actin polymerization. According to this hypothesis activated ARP2/3 complex binds to the side of a pre?existing (mother) actin filament and induces the formation of end?side junctions between filaments by linking the pointed end of a newly nucleated filament to the side of a pre?existing one (Thomas et al. 2004, Mullins et al. 1998). Branching occur preferentially near the barbed end of the mother filament. The ARP2/3 complex acts as a pointed end capper for the nascent daughter filament and the two ARPs forms the first two subunits in this daughter filament. ATP hydrolysis on G?actin after incorporation at the branch destabilises its interaction with membrane?bound activator, leading to detachment of the branched junction (Le Clainche & Carlier 2008, Le Clainche et al. 2003). |
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