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Details on Person Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK4...

Class:IdSummation:2028685
_displayNameCytosolic LATS1 and LATS2 are phosphorylated by phospho-STK4...
_timestamp2012-02-03 21:07:39
created[InstanceEdit:2028678] D'Eustachio, P, 2011-12-30
modified[InstanceEdit:2028699] D'Eustachio, P, 2011-12-30
[InstanceEdit:2085534] D'Eustachio, P, 2012-02-03
textCytosolic LATS1 and LATS2 are phosphorylated by phospho-STK4(MST1)/N (Graves et al. 1998; Lee et al. 2001). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Serine-909 and threonine-1097 have been identified as LATS1 residues phosphorylated by STK4 (MST1) kinase. The target residues of LATS2 have not been identified experiemntally but are inferred to be serine-871 and threonine-1041 based on sequence similarity.
(summation)[Reaction:2028679] Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N [Homo sapiens]
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