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Details on Person Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)

Class:Id	Reaction:2028589
_displayName	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
_doRelease	TRUE
_timestamp	2012-03-01 11:22:02
authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
catalystActivity	[CatalystActivity:2028573] protein serine/threonine kinase activity of p-STK3:p-SAV1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643879] protein serine/threonine kinase activity of p-STK3:p-SAV1 [cytosol] The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2028547] D'Eustachio, P, 2011-12-28
edited	[InstanceEdit:2028654] D'Eustachio, P, 2011-12-30
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:2028543] LATS:p-MOB [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2028282] The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
modified	[InstanceEdit:2028601] D'Eustachio, P, 2011-12-28 [InstanceEdit:2028621] D'Eustachio, P, 2011-12-29 [InstanceEdit:2028655] D'Eustachio, P, 2011-12-30 [InstanceEdit:2085534] D'Eustachio, P, 2012-02-03 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:2028550] p-LATS:p-MOB [cytosol] [Homo sapiens]
precedingEvent	[Reaction:2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 [Homo sapiens] [Reaction:2028626] Phosphorylated MOB1A proteins associate with LATS proteins [Homo sapiens] [Reaction:2028635] Phosphorylation of MOB1A and B by p-STK3 (p-MST2) [Homo sapiens] [Reaction:2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N [Homo sapiens] [Reaction:2028629] Phosphorylation of MOB1A and B by p-STK4 (p-MST1) [Homo sapiens] [Reaction:2028670] Phosphorylation of MOB1A and B by p-STK4(MST1)/N [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158099] R-HSA-2028589.3
summation	[Summation:2028599] Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3...
(hasEvent)	[Pathway:2028269] Signaling by Hippo [Homo sapiens]
(precedingEvent)	[Reaction:2028583] Phosphorylation of YAP by LATS2 [Homo sapiens] [Reaction:2028598] Phosphorylation of YAP by LATS1 [Homo sapiens] [Reaction:2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 [Homo sapiens] [Reaction:2060328] Phosphorylation of WWTR1 (TAZ) by LATS1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846725] Update Tracker - [Reaction:2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - v84:[modifyText]
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No pathways have been reviewed or authored by Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (2028589)