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Details on Person Some HSPGs are secreted to the plasma membrane

Class:Id	BlackBoxEvent:2024108
_displayName	Some HSPGs are secreted to the plasma membrane
_doRelease	TRUE
_timestamp	2025-07-18 20:38:15
authored	[InstanceEdit:2024092] Jassal, B, 2011-12-14
compartment	[Compartment:17963] Golgi lumen [Compartment:876] plasma membrane
created	[InstanceEdit:2024092] Jassal, B, 2011-12-14
edited	[InstanceEdit:2024092] Jassal, B, 2011-12-14
goBiologicalProcess	[GO_BiologicalProcess:160306] Golgi to plasma membrane protein transport
input	[DefinedSet:2076619] HSPGs [Golgi lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1666986] Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions
modified	[InstanceEdit:2024118] Jassal, B, 2011-12-14 [InstanceEdit:2046181] Jassal, B, 2012-01-11 [InstanceEdit:2076352] Jassal, B, 2012-01-27 [InstanceEdit:2090024] Jassal, B, 2012-02-06 [InstanceEdit:2161486] Jassal, B, 2012-03-14 [InstanceEdit:2161487] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2318608] Jassal, B, 2012-06-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2429636] Jupe, S, 2012-08-09 [InstanceEdit:2457601] Jassal, B, 2012-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941465] Stephan, Ralf, 2025-03-07 [InstanceEdit:9961094] D'Eustachio, Peter, 2025-07-18
name	Some HSPGs are secreted to the plasma membrane
output	[DefinedSet:2076618] HSPGs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) [Homo sapiens] [Reaction:2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens] [Reaction:2024100] GLCE epimerises GlcA to IdoA [Homo sapiens] [Reaction:2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) [Homo sapiens] [Reaction:2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises [Homo sapiens] [Reaction:2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate [Homo sapiens] [Reaction:2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate [Homo sapiens] [Reaction:2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate [Homo sapiens] [Reaction:2024100] GLCE epimerises GlcA to IdoA [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens] [Reaction:2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate [Homo sapiens] [Reaction:2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens] [Reaction:2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate [Homo sapiens] [Reaction:2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens] [Reaction:2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin [Homo sapiens] [Reaction:2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294921] R-HSA-2024108.4
summation	[Summation:2024087] Depending on the nature of the core protein HS-GAGs are atta...
(hasEvent)	[Pathway:2022928] HS-GAG biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans [Homo sapiens] [BlackBoxEvent:2024084] HS-GAGs translocate to the lysosome for degradation [Homo sapiens] [Reaction:9792569] proHPSE binds SDC1 [Homo sapiens]
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No pathways have been reviewed or authored by Some HSPGs are secreted to the plasma membrane (2024108)