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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of Inositol phosphate metabolism

Class:IdPathwayDiagram:2024078
_displayNameDiagram of Inositol phosphate metabolism
_timestamp2025-12-16 21:43:59
created[InstanceEdit:2024083] Williams, MG, 2011-12-14
height1472
modified[InstanceEdit:2024122] Williams, MG, 2011-12-14
[InstanceEdit:2193078] Wu, G, 2012-04-11
[InstanceEdit:2532797] D'Eustachio, P, 2012-10-19
[InstanceEdit:2562613] D'Eustachio, P, 2012-11-06
[InstanceEdit:2562615] D'Eustachio, P, 2012-11-06
[InstanceEdit:2563641] D'Eustachio, P, 2012-11-07
[InstanceEdit:2564838] D'Eustachio, P, 2012-11-07
[InstanceEdit:2566982] D'Eustachio, P, 2012-11-09
[InstanceEdit:2568016] D'Eustachio, P, 2012-11-10
[InstanceEdit:3769051] Gillespie, ME, 2013-06-19
[InstanceEdit:5678343] Jassal, Bijay, 2015-02-23
[InstanceEdit:5678344] Jassal, Bijay, 2015-02-23
[InstanceEdit:5678416] Jassal, Bijay, 2015-02-24
[InstanceEdit:6809562] Orlic-Milacic, Marija, 2015-11-11
[InstanceEdit:6809569] Orlic-Milacic, Marija, 2015-11-11
[InstanceEdit:6809689] Orlic-Milacic, Marija, 2015-11-12
[InstanceEdit:6810044] Orlic-Milacic, Marija, 2015-11-13
[InstanceEdit:8848435] D'Eustachio, Peter, 2015-12-08
[InstanceEdit:8955383] Jassal, Bijay, 2017-01-11
[InstanceEdit:8957409] Orlic-Milacic, Marija, 2017-01-25
[InstanceEdit:9033264] Jassal, Bijay, 2017-12-20
[InstanceEdit:9947651] D'Eustachio, Peter, 2025-05-09
[InstanceEdit:9954157] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9966360] Stephan, Ralf, 2025-09-21
[InstanceEdit:9966590] Stephan, Ralf, 2025-09-22
[InstanceEdit:9966626] D'Eustachio, Peter, 2025-09-23
[InstanceEdit:9966628] D'Eustachio, Peter, 2025-09-23
[InstanceEdit:9968055] D'Eustachio, Peter, 2025-10-08
[InstanceEdit:9977080] D'Eustachio, Peter, 2025-12-16
representedPathway[Pathway:1483249] Inositol phosphate metabolism [Homo sapiens]
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points="600 104" /> </Inputs> <Outputs> <Output id="1184" points="724 46" /> <Output id="23" points="765 187" /> <Output id="1222" points="733 82" /> </Outputs> <Catalysts> <Catalyst id="24" points="657 38" /> </Catalysts> <Properties> <displayName>PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="30" reactomeId="1855177" points="597 86, 657 93, 695 94" position="657 93" lineWidth="1.0"> <Inputs> <Input id="20" points="580 44" /> <Input id="21" points="594 104" /> </Inputs> <Outputs> <Output id="1184" points="728 46" /> <Output id="23" points="764 187" /> <Output id="1222" points="733 88" /> </Outputs> <Catalysts> <Catalyst id="32" points="657 126" /> </Catalysts> <Properties> <displayName>PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="1855214" points="623 261, 664 261, 693 260" position="664 261" lineWidth="1.0"> <Inputs> <Input id="45" points="588 299" /> <Input id="177" points="577 261" /> </Inputs> <Outputs> <Output id="47" points="721 299" /> <Output id="23" points="752 223" /> <Output id="1220" points="721 263" /> </Outputs> <Catalysts> <Catalyst id="1185" points="590 363" /> </Catalysts> <Properties> <displayName>PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="148" reactomeId="1855200" points="735 434, 736 407, 735 379" position="736 407" lineWidth="1.0"> <Inputs> <Input id="1033" points="653 465" /> <Input id="150" points="735 460" /> </Inputs> <Outputs> <Output id="152" points="752 370" /> <Output id="1034" points="711 369" /> </Outputs> <Catalysts> <Catalyst id="153" points="763 399" /> </Catalysts> <Properties> <displayName>I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="154" reactomeId="1855217" points="774 334, 774 318, 774 223" position="774 318" lineWidth="1.0"> <Inputs> <Input id="152" /> </Inputs> <Outputs> <Output id="23" /> </Outputs> <Catalysts> <Catalyst id="1213" points="797 315" /> </Catalysts> <Properties> <displayName>I(1,4,5)P3 transports from the ER lumen to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="1855211" points="242 250, 215 300, 215 343" position="215 300" lineWidth="1.0"> <Inputs> <Input id="156" points="255 233" /> <Input id="157" points="262 256" /> </Inputs> <Outputs> <Output id="158" points="179 365" /> <Output id="159" points="242 361" /> </Outputs> <Catalysts> <Catalyst id="160" points="324 298" /> </Catalysts> <Properties> <displayName>I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="178" reactomeId="1855174" points="680 223, 599 198, 554 197" position="599 198" lineWidth="1.0"> <Inputs> <Input id="179" points="691 194" /> <Input id="23" points="737 211" /> </Inputs> <Outputs> <Output id="180" points="478 162" /> <Output id="183" points="508 219" /> </Outputs> <Catalysts> <Catalyst id="181" points="600 212" /> </Catalysts> <Properties> <displayName>I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="184" reactomeId="1855222" points="697 210, 571 172, 546 171" position="571 172" lineWidth="1.0"> <Inputs> <Input id="23" points="737 207" /> <Input id="179" points="697 194" /> </Inputs> <Outputs> <Output id="180" points="484 152" /> <Output id="183" points="505 209" /> </Outputs> <Catalysts> <Catalyst id="186" points="505 41" /> </Catalysts> <Properties> <displayName>I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="199" reactomeId="1855208" points="386 184, 352 184, 319 183" position="352 184" lineWidth="1.0"> <Inputs> <Input id="200" points="409 200" /> <Input id="180" points="425 162" /> </Inputs> <Outputs> <Output id="156" points="288 203" /> <Output id="203" points="299 164" /> </Outputs> <Catalysts> <Catalyst id="201" points="350 147" /> </Catalysts> <Properties> <displayName>I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="219" reactomeId="1855154" points="413 421, 360 420, 313 419" position="360 420" lineWidth="1.0"> <Inputs> <Input id="1036" points="456 373" /> <Input id="221" points="441 428" /> </Inputs> <Outputs> <Output id="159" points="280 392" /> <Output id="223" points="303 429" /> </Outputs> <Catalysts> <Catalyst id="160" points="359 315" /> </Catalysts> <Properties> <displayName>I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="229" reactomeId="1855210" points="213 534, 214 471, 214 401" position="214 471" lineWidth="1.0"> <Inputs> <Input id="230" points="190 534" /> <Input id="231" points="248 534" /> </Inputs> <Outputs> <Output id="158" points="179 381" /> <Output id="159" points="242 384" /> </Outputs> <Catalysts> <Catalyst id="232" points="190 469" /> </Catalysts> <Properties> <displayName>I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="238" reactomeId="1855178" points="268 625, 268 589, 268 553" position="268 589" lineWidth="1.0"> <Inputs> <Input id="239" /> </Inputs> <Outputs> <Output id="231" /> </Outputs> <Catalysts> <Catalyst id="240" points="307 589" /> </Catalysts> <Properties> <displayName>Glc6P is isomerised to I3P by ISYNA1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="251" reactomeId="1855202" points="418 472, 368 471, 303 472" position="368 471" lineWidth="1.0"> <Inputs> <Input id="253" points="449 519" /> <Input id="221" points="446 451" /> </Inputs> <Outputs> <Output id="231" points="276 517" /> <Output id="223" points="294 460" /> </Outputs> <Catalysts> <Catalyst id="254" points="368 508" /> </Catalysts> <Properties> <displayName>I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="255" reactomeId="1855232" points="688 589, 630 589, 499 588" position="630 589" lineWidth="1.0"> <Inputs> <Input id="256" points="751 620" /> <Input id="257" points="711 563" /> </Inputs> <Outputs> <Output id="253" points="470 555" /> <Output id="260" points="477 612" /> </Outputs> <Catalysts> <Catalyst id="258" points="627 559" /> </Catalysts> <Properties> <displayName>I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="271" reactomeId="1855180" points="725 692, 724 738, 724 795" position="724 738" lineWidth="1.0"> <Inputs> <Input id="256" points="764 656" /> <Input id="272" points="697 659" /> </Inputs> <Outputs> <Output id="273" points="691 812" /> <Output id="275" points="741 821" /> </Outputs> <Catalysts> <Catalyst id="276" points="693 738" /> </Catalysts> <Properties> <displayName>I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="287" reactomeId="1855186" points="891 480, 836 479, 783 478" position="836 479" lineWidth="1.0"> <Inputs> <Input id="288" /> </Inputs> <Outputs> <Output id="150" /> </Outputs> <Catalysts> <Catalyst id="1213" points="838 334" /> </Catalysts> <Properties> <displayName>I(1,3,4,5)P4 transports from the cytosol to the ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="289" reactomeId="1855153" points="883 244, 937 311, 936 359" position="937 311" lineWidth="1.0"> <Inputs> <Input id="290" points="835 253" /> <Input id="23" points="814 217" /> </Inputs> <Outputs> <Output id="288" points="936 463" /> <Output id="1224" points="903 394" /> <Output id="291" points="985 372" /> </Outputs> <Catalysts> <Catalyst id="292" points="898 338" /> </Catalysts> <Properties> <displayName>I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="298" reactomeId="1855205" points="966 399, 954 298, 895 228" position="954 298" lineWidth="1.0"> <Inputs> <Input id="299" points="999 407" /> <Input id="288" points="942 463" /> </Inputs> <Outputs> <Output id="23" points="814 211" /> <Output id="302" points="932 228" /> </Outputs> <Catalysts> <Catalyst id="300" points="995 288" /> </Catalysts> <Properties> <displayName>I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="303" reactomeId="1855218" points="894 521, 864 553, 832 579" position="864 553" lineWidth="1.0"> <Inputs> <Input id="304" points="927 523" /> <Input id="288" points="920 499" /> </Inputs> <Outputs> <Output id="256" points="792 620" /> <Output id="307" points="778 591" /> </Outputs> <Catalysts> <Catalyst id="305" points="844 546" /> </Catalysts> <Properties> <displayName>I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="313" reactomeId="1855213" points="907 538, 887 559, 836 597" position="887 559" lineWidth="1.0"> <Inputs> <Input id="288" points="929 499" /> <Input id="304" points="927 531" /> </Inputs> <Outputs> <Output id="256" points="799 620" /> <Output id="307" points="778 595" /> </Outputs> <Catalysts> <Catalyst id="1136" points="1002 634" /> </Catalysts> <Properties> <displayName>I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="339" reactomeId="1855172" points="893 612, 952 564, 1001 513" position="952 564" lineWidth="1.0"> <Inputs> <Input id="256" points="820 629" /> <Input id="355" points="921 637" /> </Inputs> <Outputs> <Output id="1216" points="1028 534" /> <Output id="288" points="967 499" /> <Output id="1228" points="1031 499" /> </Outputs> <Catalysts> <Catalyst id="367" points="994 578" /> </Catalysts> <Properties> <displayName>I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="354" reactomeId="1855197" points="877 687, 876 741, 895 773" position="876 741" lineWidth="1.0"> <Inputs> <Input id="256" points="809 656" /> <Input id="355" points="914 665" /> </Inputs> <Outputs> <Output id="357" points="926 806" /> <Output id="1230" points="942 784" /> <Output id="356" points="929 758" /> </Outputs> <Catalysts> <Catalyst id="342" points="910 722" /> </Catalysts> <Properties> <displayName>I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="363" reactomeId="1855171" points="817 781, 816 737, 817 683" position="816 737" lineWidth="1.0"> <Inputs> <Input id="364" points="797 789" /> <Input id="357" points="896 806" /> </Inputs> <Outputs> <Output id="256" points="791 656" /> <Output id="366" points="780 693" /> </Outputs> <Catalysts> <Catalyst id="342" points="884 718" /> </Catalysts> <Properties> <displayName>I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="368" reactomeId="1855159" points="889 872, 889 928, 890 958" position="889 928" lineWidth="1.0"> <Inputs> <Input id="357" points="923 842" /> <Input id="369" points="868 863" /> </Inputs> <Outputs> <Output id="370" points="920 988" /> <Output id="377" points="862 986" /> </Outputs> <Catalysts> <Catalyst id="379" points="848 922" /> </Catalysts> <Properties> <displayName>I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="380" reactomeId="1855169" points="972 958, 969 910, 969 876" position="969 910" lineWidth="1.0"> <Inputs> <Input id="370" points="945 988" /> <Input id="381" points="1008 991" /> </Inputs> <Outputs> <Output id="357" points="947 842" /> <Output id="1232" points="1048 870" /> <Output id="382" points="1002 856" /> </Outputs> <Catalysts> <Catalyst id="379" points="848 915" /> </Catalysts> <Properties> <displayName>I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="398" reactomeId="1855190" points="814 202, 1153 174, 1188 175" position="1153 174" lineWidth="1.0"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="399" /> </Outputs> <Catalysts> <Catalyst id="1269" points="1152 282" /> </Catalysts> <Properties> <displayName>I(1,4,5)P3 transports from the cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="405" reactomeId="1855168" points="984 474, 1154 447, 1182 447" position="1154 447" lineWidth="1.0"> <Inputs> <Input id="288" /> </Inputs> <Outputs> <Output id="406" /> </Outputs> <Catalysts> <Catalyst id="1269" points="1152 347" /> </Catalysts> <Properties> <displayName>I(1,3,4,5)P4 transports from the cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="407" reactomeId="1855201" points="986 817, 1155 790, 1187 790" position="1155 790" lineWidth="1.0"> <Inputs> <Input id="357" /> </Inputs> <Outputs> <Output id="408" /> </Outputs> <Catalysts> <Catalyst id="1270" points="1153 756" /> </Catalysts> <Properties> <displayName>I(1,3,4,6)P4 transports from the cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="414" reactomeId="1855185" points="1303 658, 1352 659, 1385 658" position="1352 659" lineWidth="1.0"> <Inputs> <Input id="416" points="1266 645" /> <Input id="445" points="1282 700" /> </Inputs> <Outputs> <Output id="418" points="1430 643" /> <Output id="417" points="1408 686" /> <Output id="1255" points="1381 625" /> </Outputs> <Catalysts> <Catalyst id="419" points="1352 693" /> </Catalysts> <Properties> <displayName>I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="420" reactomeId="1855233" points="1244 227, 1244 306, 1244 367" position="1244 306" lineWidth="1.0"> <Inputs> <Input id="399" points="1232 195" /> <Input id="421" points="1284 195" /> </Inputs> <Outputs> <Output id="406" points="1231 429" /> <Output id="1253" points="1215 386" /> <Output id="422" points="1290 428" /> </Outputs> <Catalysts> <Catalyst id="423" points="1288 305" /> </Catalysts> <Properties> <displayName>I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="429" reactomeId="1855206" points="1286 507, 1329 532, 1363 555" position="1329 532" lineWidth="1.0"> <Inputs> <Input id="430" points="1212 501" /> <Input id="406" points="1242 465" /> </Inputs> <Outputs> <Output id="1264" points="1323 568" /> <Output id="418" points="1445 607" /> </Outputs> <Catalysts> <Catalyst id="443" points="1339 508" /> </Catalysts> <Properties> <displayName>I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="444" reactomeId="1855228" points="1321 756, 1354 756, 1445 755" position="1354 756" lineWidth="1.0"> <Inputs> <Input id="408" points="1271 772" /> <Input id="445" points="1293 736" /> </Inputs> <Outputs> <Output id="418" points="1465 643" /> <Output id="1263" points="1482 753" /> <Output id="417" points="1427 722" /> </Outputs> <Catalysts> <Catalyst id="419" points="1352 721" /> </Catalysts> <Properties> <displayName>I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="467" reactomeId="1855176" points="1557 646, 1600 656, 1661 676" position="1600 656" lineWidth="1.0"> <Inputs> <Input id="468" points="1535 661" /> <Input id="418" points="1521 636" /> </Inputs> <Outputs> <Output id="469" points="1687 772" /> <Output id="1257" points="1708 707" /> <Output id="470" points="1718 677" /> </Outputs> <Catalysts> <Catalyst id="471" points="1599 690" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="472" reactomeId="1855181" points="1527 572, 1606 571, 1664 571" position="1606 571" lineWidth="1.0"> <Inputs> <Input id="473" points="1507 554" /> <Input id="418" points="1484 607" /> </Inputs> <Outputs> <Output id="1055" points="1687 577" /> <Output id="1053" points="1664 418" /> </Outputs> <Catalysts> <Catalyst id="476" points="1581 398" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="477" reactomeId="1855230" points="1693 360, 1694 334, 1694 298" position="1694 334" lineWidth="1.0"> <Inputs> <Input id="1062" points="1725 367" /> <Input id="1053" points="1674 382" /> </Inputs> <Outputs> <Output id="1064" points="1653 267" /> <Output id="1066" points="1724 277" /> </Outputs> <Catalysts> <Catalyst id="476" points="1606 364" /> </Catalysts> <Properties> <displayName>5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="501" reactomeId="1855207" points="1666 829, 1666 853, 1666 892" position="1666 853" lineWidth="1.0"> <Inputs> <Input id="469" points="1681 808" /> <Input id="502" points="1648 822" /> </Inputs> <Outputs> <Output id="503" points="1685 914" /> <Output id="504" points="1644 905" /> </Outputs> <Catalysts> <Catalyst id="505" points="1599 877" /> </Catalysts> <Properties> <displayName>IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="511" reactomeId="1855224" points="1623 961, 1586 960, 1556 960" position="1586 960" lineWidth="1.0"> <Inputs> <Input id="503" points="1659 945" /> <Input id="512" points="1666 988" /> </Inputs> <Outputs> <Output id="513" points="1517 945" /> <Output id="514" points="1529 982" /> </Outputs> <Catalysts> <Catalyst id="505" points="1567 904" /> </Catalysts> <Properties> <displayName>5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="520" reactomeId="1855188" points="1864 792, 1791 791, 1712 790" position="1791 791" lineWidth="1.0"> <Inputs> <Input id="521" /> </Inputs> <Outputs> <Output id="469" /> </Outputs> <Catalysts> <Catalyst id="1274" points="1779 832" /> </Catalysts> <Properties> <displayName>IP6 transports from the cytosol to the nucleus</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="522" reactomeId="1855203" points="1736 931, 1793 930, 1865 930" position="1793 930" lineWidth="1.0"> <Inputs> <Input id="503" /> </Inputs> <Outputs> <Output id="523" /> </Outputs> <Catalysts> <Catalyst id="1274" points="1780 897" /> </Catalysts> <Properties> <displayName>5-PP-IP5 transports from the nucleus to the cytosol</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="534" reactomeId="1855182" points="1921 981, 1922 1015, 1922 1039" position="1922 1015" lineWidth="1.0"> <Inputs> <Input id="535" points="1944 971" /> <Input id="523" points="1908 948" /> </Inputs> <Outputs> <Output id="1127" points="2009 1041" /> <Output id="1124" points="2008 1088" /> </Outputs> <Catalysts> <Catalyst id="538" points="2050 1012" /> </Catalysts> <Properties> <displayName>5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="546" reactomeId="1855194" points="2034 1193, 2033 1168, 2034 1142" position="2033 1168" lineWidth="1.0"> <Inputs> <Input id="1119" points="2044 1243" /> <Input id="1132" points="2007 1210" /> </Inputs> <Outputs> <Output id="1124" points="2033 1124" /> <Output id="537" points="2066 1142" /> </Outputs> <Catalysts> <Catalyst id="550" points="2002 1166" /> </Catalysts> <Properties> <displayName>1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="551" reactomeId="1855165" points="1833 1050, 1832 1009, 1832 972" position="1832 1009" lineWidth="1.0"> <Inputs> <Input id="536" points="1894 1086" /> <Input id="582" points="1860 1054" /> </Inputs> <Outputs> <Output id="523" points="1877 948" /> <Output id="555" points="1869 969" /> </Outputs> <Catalysts> <Catalyst id="580" points="1853 1011" /> </Catalysts> <Properties> <displayName>(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="561" reactomeId="2023973" points="1917 1154, 1916 1183, 1917 1214" position="1916 1183" lineWidth="1.0"> <Inputs> <Input id="536" points="1917 1128" /> <Input id="552" points="1886 1143" /> </Inputs> <Outputs> <Output id="548" points="1929 1240" /> <Output id="564" points="1875 1233" /> </Outputs> <Catalysts> <Catalyst id="553" points="1884 1181" /> </Catalysts> <Properties> <displayName>(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="598" reactomeId="1855212" points="1887 1261, 1792 1261, 1770 1261" position="1792 1261" lineWidth="1.0"> <Inputs> <Input id="548" /> </Inputs> <Outputs> <Output id="599" /> </Outputs> <Catalysts> <Catalyst id="1278" points="1788 1213" /> </Catalysts> <Properties> <displayName>1/3-PP-IP5 transports from the cytosol to the nucleus</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="600" reactomeId="1855220" points="1762 1105, 1791 1105, 1875 1106" position="1791 1105" lineWidth="1.0"> <Inputs> <Input id="601" /> </Inputs> <Outputs> <Output id="536" /> </Outputs> <Catalysts> <Catalyst id="1278" points="1788 1147" /> </Catalysts> <Properties> <displayName>(PP)2-IP4 transports from the nucleus to the cytosol</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="607" reactomeId="1855157" points="1559 1213, 1560 1178, 1561 1145" position="1560 1178" lineWidth="1.0"> <Inputs> <Input id="1085" points="1593 1243" /> <Input id="1240" points="1506 1218" /> <Input id="1089" points="1535 1251" /> </Inputs> <Outputs> <Output id="1094" points="1528 1119" /> <Output id="1090" points="1590 1123" /> </Outputs> <Catalysts> <Catalyst id="611" points="1601 1178" /> </Catalysts> <Properties> <displayName>1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="642" reactomeId="1855198" points="1859 889, 1858 860, 1859 835" position="1858 860" lineWidth="1.0"> <Inputs> <Input id="643" points="1852 895" /> <Input id="523" points="1886 912" /> </Inputs> <Outputs> <Output id="521" points="1875 811" /> <Output id="645" points="1837 821" /> </Outputs> <Catalysts> <Catalyst id="647" points="1878 860" /> </Catalysts> <Properties> <displayName>5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="653" reactomeId="1855227" points="1945 830, 1945 861, 1946 891" position="1945 861" lineWidth="1.0"> <Inputs> <Input id="654" points="1963 821" /> <Input id="521" points="1905 803" /> </Inputs> <Outputs> <Output id="523" points="1919 912" /> <Output id="655" points="1961 896" /> </Outputs> <Catalysts> <Catalyst id="657" points="1987 861" /> </Catalysts> <Properties> <displayName>IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="663" reactomeId="1855158" points="1989 929, 2022 929, 2056 929" position="2022 929" lineWidth="1.0"> <Inputs> <Input id="523" points="1942 929" /> <Input id="535" points="1976 946" /> </Inputs> <Outputs> <Output id="665" points="2085 929" /> <Output id="666" points="2067 950" /> </Outputs> <Catalysts> <Catalyst id="657" points="2021 879" /> </Catalysts> <Properties> <displayName>5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="674" reactomeId="1855216" points="2027 787, 2186 899, 2186 1011, 2140 1141" position="2186 1011" lineWidth="1.0"> <Inputs> <Input id="521" points="1905 792" /> <Input id="654" points="2009 800" /> </Inputs> <Outputs> <Output id="1119" points="2059 1243" /> <Output id="537" points="2113 1142" /> </Outputs> <Catalysts> <Catalyst id="538" points="2133 1011" /> </Catalysts> <Properties> <displayName>IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="677" reactomeId="2023971" points="2098 1300, 2207 1014, 2207 895, 2036 775" position="2207 1014" lineWidth="1.0"> <Inputs> <Input id="678" points="2062 1322" /> <Input id="548" points="1984 1271" /> </Inputs> <Outputs> <Output id="521" points="1905 790" /> <Output id="680" points="1996 766" /> </Outputs> <Catalysts> <Catalyst id="682" points="2232 1014" /> </Catalysts> <Properties> <displayName>1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="698" reactomeId="1855161" points="1521 625, 1789 627, 1839 629" position="1789 627" lineWidth="1.0"> <Inputs> <Input id="418" /> </Inputs> <Outputs> <Output id="699" /> </Outputs> <Catalysts> <Catalyst id="1282" points="1775 521" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 transports from the nucleus to the cytosol</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="700" reactomeId="1855173" points="1703 400, 1791 400, 1837 400" position="1791 400" lineWidth="1.0"> <Inputs> <Input id="1053" /> </Inputs> <Outputs> <Output id="1071" /> </Outputs> <Catalysts> <Catalyst id="1282" points="1778 454" /> </Catalysts> <Properties> <displayName>5-PP-IP4 transports from the nucleus to the cytosol</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="707" reactomeId="1855193" points="1866 315, 1866 276, 1867 248" position="1866 276" lineWidth="1.0"> <Inputs> <Input id="1100" points="1914 341" /> <Input id="1104" points="1847 329" /> </Inputs> <Outputs> <Output id="1109" points="1849 227" /> <Output id="1106" points="1906 225" /> </Outputs> <Catalysts> <Catalyst id="712" points="1893 274" /> </Catalysts> <Properties> <displayName>1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="728" reactomeId="1855179" points="1873 675, 1872 702, 1873 738" position="1872 702" lineWidth="1.0"> <Inputs> <Input id="699" points="1884 649" /> <Input id="729" points="1843 663" /> </Inputs> <Outputs> <Output id="521" points="1881 775" /> <Output id="730" points="1842 753" /> </Outputs> <Catalysts> <Catalyst id="731" points="1839 702" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="742" reactomeId="1855166" points="1940 478, 1941 512, 1941 577" position="1941 512" lineWidth="1.0"> <Inputs> <Input id="743" points="1987 450" /> <Input id="701" points="1940 460" /> </Inputs> <Outputs> <Output id="699" points="1904 613" /> <Output id="750" points="1922 557" /> </Outputs> <Catalysts> <Catalyst id="744" points="1986 497" /> </Catalysts> <Properties> <displayName>PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="756" reactomeId="1855223" points="1875 561, 1885 512, 1874 465" position="1885 512" lineWidth="1.0"> <Inputs> <Input id="699" points="1887 613" /> <Input id="757" points="1846 585" /> </Inputs> <Outputs> <Output id="1097" points="1857 450" /> <Output id="1071" points="1874 418" /> </Outputs> <Catalysts> <Catalyst id="760" points="1850 530" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="771" reactomeId="1855219" points="1999 592, 2044 592, 2079 593" position="2044 592" lineWidth="1.0"> <Inputs> <Input id="772" points="1996 553" /> <Input id="699" points="1932 613" /> </Inputs> <Outputs> <Output id="773" points="2095 608" /> <Output id="775" points="2095 581" /> </Outputs> <Catalysts> <Catalyst id="777" points="2068 541" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="778" reactomeId="1855162" points="2040 612, 2012 612, 1992 612" position="2012 612" lineWidth="1.0"> <Inputs> <Input id="773" points="2064 617" /> <Input id="782" points="2038 638" /> </Inputs> <Outputs> <Output id="780" points="1970 638" /> <Output id="699" points="1944 621" /> </Outputs> <Catalysts> <Catalyst id="777" points="2065 541" /> </Catalysts> <Properties> <displayName>I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="799" reactomeId="1855163" points="2397 642, 2396 703, 2396 745" position="2396 703" lineWidth="1.0"> <Inputs> <Input id="801" points="2377 616" /> <Input id="1037" points="2428 618" /> </Inputs> <Outputs> <Output id="802" points="2412 781" /> <Output id="1040" points="2373 764" /> </Outputs> <Catalysts> <Catalyst id="806" points="2370 702" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="807" reactomeId="1855225" points="2257 757, 2258 727, 2259 690" position="2258 727" lineWidth="1.0"> <Inputs> <Input id="809" points="2257 783" /> <Input id="1038" points="2277 766" /> </Inputs> <Outputs> <Output id="1135" points="2279 662" /> <Output id="1042" points="2235 674" /> </Outputs> <Catalysts> <Catalyst id="806" points="2311 710" /> </Catalysts> <Properties> <displayName>IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="853" reactomeId="1855155" points="2318 579, 2295 574, 2193 575, 2162 680, 1927 680, 1902 649" position="2162 680" lineWidth="1.0"> <Inputs> <Input id="801" /> </Inputs> <Outputs> <Output id="699" /> </Outputs> <Catalysts> <Catalyst id="1214" points="2170 725" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="854" reactomeId="1855195" points="1897 649, 1922 698, 2182 699, 2208 595, 2316 596" position="2182 699" lineWidth="1.0"> <Inputs> <Input id="699" /> </Inputs> <Outputs> <Output id="801" /> </Outputs> <Catalysts> <Catalyst id="1214" points="2177 725" /> </Catalysts> <Properties> <displayName>I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="860" reactomeId="1855164" points="1905 781, 1975 733, 2173 796, 2237 799" position="2173 796" lineWidth="1.0"> <Inputs> <Input id="521" /> </Inputs> <Outputs> <Output id="809" /> </Outputs> <Catalysts> <Catalyst id="1214" points="2173 768" /> </Catalysts> <Properties> <displayName>IP6 transports from the cytosol to the ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="861" reactomeId="1855187" points="1671 789, 1424 788, 1424 1307, 1424 1372, 2300 1371, 2300 886, 2264 819" position="1424 1307" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="469" /> </Inputs> <Outputs> <Output id="809" /> </Outputs> <Properties> <displayName>IP6 transports from the nucleus to the ER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="882" reactomeId="1855189" points="2404 817, 2333 889, 2334 1391, 1102 1386, 1096 709, 1151 628, 1187 627" position="1151 628" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="802" /> </Inputs> <Outputs> <Output id="416" /> </Outputs> <Properties> <displayName>I(1,4,5,6)P4 transports from the ER lumen to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="888" reactomeId="1855160" points="2364 579, 2306 164, 1791 166, 1466 167, 1467 607" position="1791 166" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="801" /> </Inputs> <Outputs> <Output id="418" /> </Outputs> <Properties> <displayName>I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="895" interactionType="Activate" points="761 34, 851 83" position="806 58" lineWidth="2.0"> <Outputs> <Output id="894" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1027" interactionType="Activate" points="795 187, 861 143" position="828 165" lineWidth="2.0"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="894" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.EntitySetAndMemberLink id="1072" points="1893 418, 1907 426" position="1900 422" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1071" /> </Inputs> <Outputs> <Output id="701" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1086" points="1648 1259, 1673 1259" position="1660 1259" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1085" /> </Inputs> <Outputs> <Output id="599" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1091" points="1664 1105, 1678 1105" position="1671 1105" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1090" /> </Inputs> <Outputs> <Output id="601" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1101" points="1939 377, 1940 418" position="1939 397" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1100" /> </Inputs> <Outputs> <Output id="701" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1120" points="2011 1259, 1984 1259" position="1997 1259" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1119" /> </Inputs> <Outputs> <Output id="548" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1125" points="1980 1105, 1959 1105" position="1969 1105" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1124" /> </Inputs> <Outputs> <Output id="536" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1146" reactomeId="5678327" points="223 710, 223 747, 223 778" position="223 747" lineWidth="1.0"> <Inputs> <Input id="159" points="262 392" /> <Input id="1147" points="194 684" /> </Inputs> <Outputs> <Output id="1148" points="223 832" /> <Output id="1149" points="252 794" /> <Output id="1150" points="291 766" /> </Outputs> <Catalysts> <Catalyst id="1151" points="195 747" /> </Catalysts> <Properties> <displayName>MIOX oxidises Ins to GlcA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1163" reactomeId="6809561" points="521 734, 520 715, 513 402" position="520 715" lineWidth="1.0"> <Inputs> <Input id="273" points="644 812" /> <Input id="1164" points="501 761" /> </Inputs> <Outputs> <Output id="1036" points="483 373" /> <Output id="1167" points="511 346" /> </Outputs> <Catalysts> <Catalyst id="1165" points="492 715" /> </Catalysts> <Properties> <displayName>I(1,3)P2 is dephosphorylated into I1P by MTMR7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1178" reactomeId="6809238" points="413 749, 412 727, 410 686" position="412 727" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1165" points="443 730" /> <Input id="1179" points="396 766" /> </Inputs> <Outputs> <Output id="1180" /> </Outputs> <Catalysts> <Catalyst id="1179" points="385 766, 384 727" /> </Catalysts> <Properties> <displayName>MTMR7 binds MTMR9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1183" reactomeId="6809565" points="540 731, 537 671, 533 451" position="537 671" lineWidth="1.0"> <Inputs> <Input id="273" points="647 812" /> <Input id="1164" points="507 761" /> </Inputs> <Outputs> <Output id="1036" points="479 373" /> <Output id="1167" points="513 346" /> </Outputs> <Catalysts> <Catalyst id="1180" points="465 671" /> </Catalysts> <Properties> <displayName>I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1188" interactionType="Activate" points="224 868, 224 933" position="224 900" lineWidth="2.0"> <Inputs> <Input id="1148" /> </Inputs> <Outputs> <Output id="1187" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Inositol phosphate metabolism (2024078)
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