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Details on Person 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol

Class:Id	Reaction:2023971
_displayName	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
_doRelease	TRUE
_timestamp	2016-11-10 00:57:10
authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023976] inositol diphosphate pentakisphosphate diphosphatase activity of NUDT(1) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2023980] Williams, MG, 2011-12-13
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
input	[DefinedSet:2023974] 1/3-PP-IP5 [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1889818] Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family [LiteratureReference:1889819] Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases [LiteratureReference:1889835] An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase [LiteratureReference:1889813] The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein [LiteratureReference:1889932] A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase [LiteratureReference:1889831] Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates
modified	[InstanceEdit:2562613] D'Eustachio, P, 2012-11-06 [InstanceEdit:2564838] D'Eustachio, P, 2012-11-07 [InstanceEdit:2565867] D'Eustachio, P, 2012-11-08 [InstanceEdit:2566982] D'Eustachio, P, 2012-11-09 [InstanceEdit:2836586] D'Eustachio, P, 2012-12-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
output	[SimpleEntity:1629770] IP6 [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Homo sapiens] [Reaction:1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Homo sapiens] [Reaction:1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Homo sapiens] [Reaction:2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Homo sapiens] [Reaction:2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol [Homo sapiens] [Reaction:1855220] (PP)2-IP4 transports from the nucleus to the cytosol [Homo sapiens] [Reaction:1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol [Homo sapiens] [Reaction:1855194] 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol [Homo sapiens]
releaseDate	2012-12-04
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200191] R-HSA-2023971.3
summation	[Summation:2023969] Diphosphoinositol polyphosphate phosphohydrolases, also know...
(hasEvent)	[Pathway:1855167] Synthesis of pyrophosphates in the cytosol [Homo sapiens]
(precedingEvent)	[Reaction:1855164] IP6 transports from the cytosol to the ER lumen [Homo sapiens] [Reaction:1855188] IP6 transports from the cytosol to the nucleus [Homo sapiens] [Reaction:1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Homo sapiens] [Reaction:1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Homo sapiens]
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