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Details on Person PI3K bound to TRAT1 phosphorylates PIP2 to PIP3

Class:Id	Reaction:202365
_displayName	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
_doRelease	TRUE
_timestamp	2016-07-22 14:22:40
authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202288] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K bound to TRAT [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
figure	[Figure:179450] /figures/pi3k_converts_pip2_2_pip3.jpg
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:202402] The role of PI3K in immune cells
modified	[InstanceEdit:202423] Garapati, P V, 2007-10-29 14:40:05 [InstanceEdit:202491] Garapati, P V, 2007-10-30 16:01:01 [InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22 [InstanceEdit:204115] de Bono, B, 2007-11-25 09:35:47 [InstanceEdit:212474] Garapati, P V, 2008-02-12 09:52:01 [InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16 [InstanceEdit:213439] Garapati, P V, 2008-02-26 11:34:22 [InstanceEdit:214480] Garapati, P V, 2008-02-26 12:04:24 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:422353] Jassal, Bijay, 2009-05-28 [InstanceEdit:422382] Jassal, Bijay, 2009-05-29 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8932232] Orlic-Milacic, Marija, 2016-07-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:202203] Recruitment of PI3K to plasma membrane [Homo sapiens] [Reaction:202407] PLC-gamma1 hydrolyses PIP2 [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360301] R-HSA-202365.3
summation	[Summation:202398] PI3K enzyme bound to adaptor protein TRIM, uses phosphatidyl...
(hasEvent)	[Pathway:202424] Downstream TCR signaling [Homo sapiens]
(precedingEvent)	[Reaction:202164] Translocation of PDK1 to Plasma membrane [Homo sapiens] [Reaction:202237] Hydrolysis of PIP3 to PI(3,4)P2 [Homo sapiens] [Reaction:2316429] PIP3 recruits PDPK1 to the membrane [Homo sapiens] [Reaction:2317332] PIP3 recruits AKT to the membrane [Homo sapiens] [Reaction:9603279] PIP3 recruits PDK1 and AKT to the membrane [Homo sapiens]
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