Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person In ZAP-70 there are multiple phosphorylation sites (Y292, Y3...
| Class:Id | Summation:202337 |
|---|---|
| _displayName | In ZAP-70 there are multiple phosphorylation sites (Y292, Y3... |
| _timestamp | 2007-11-16 10:40:48 |
| created | [InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25 |
| literatureReference | [LiteratureReference:202592] Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation |
| modified | [InstanceEdit:202597] Garapati, P V, 2007-11-07 11:54:58 [InstanceEdit:202700] Garapati, P V, 2007-11-09 12:04:27 [InstanceEdit:203257] Garapati, P V, 2007-11-12 15:37:54 [InstanceEdit:203778] Garapati, P V, 2007-11-16 10:40:11 |
| text | In ZAP-70 there are multiple phosphorylation sites (Y292, Y315, Y319, Y492, Y493) which have both positive and negative regulatory effect on its catalytic activity. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck. This phosphorylation contribute to the active conformation of the catalytic domain. |
| (summation) | [Reaction:202168] Phosphorylation of ZAP-70 by Lck [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by In ZAP-70 there are multiple phosphorylation sites (Y292, Y3... (202337)
