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Details on Person Change of PKC theta conformation

Class:Id	Reaction:202307
_displayName	Change of PKC theta conformation
_doRelease	TRUE
_timestamp	2008-06-20 09:44:51
authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202370] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
input	[Complex:202187] PKC-theta (open): DAG [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:202301] Selective function of PKC-theta in T cells [LiteratureReference:202369] Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death
modified	[InstanceEdit:202423] Garapati, P V, 2007-10-29 14:40:05 [InstanceEdit:202491] Garapati, P V, 2007-10-30 16:01:01 [InstanceEdit:203257] Garapati, P V, 2007-11-12 15:37:54 [InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22 [InstanceEdit:204115] de Bono, B, 2007-11-25 09:35:47 [InstanceEdit:212474] Garapati, P V, 2008-02-12 09:52:01 [InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16 [InstanceEdit:213437] Garapati, P V, 2008-02-26 11:30:45 [InstanceEdit:214480] Garapati, P V, 2008-02-26 12:04:24 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Change of PKC theta conformation
output	[Complex:202300] p-Y90-PKC-theta:DAG [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:202328] Translocation of PKC theta to plasma membrane [Homo sapiens] [Reaction:202164] Translocation of PDK1 to Plasma membrane [Homo sapiens] [Reaction:2730847] Hydrolysis of PIP2 by PLCG [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361989] R-HSA-202307.2
summation	[Summation:203255] PKC theta localizes at the interface between T cells and ant...
(hasEvent)	[Pathway:202424] Downstream TCR signaling [Homo sapiens]
(precedingEvent)	[Reaction:202222] Phosphorylation of PKC theta [Homo sapiens]
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No pathways have been reviewed or authored by Change of PKC theta conformation (202307)