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Query author contributions in Reactome

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Details on Person Activation of Lck

Class:IdReaction:202291
_displayNameActivation of Lck
_doReleaseTRUE
_timestamp2008-06-20 09:44:00
authored[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity[CatalystActivity:202226] protein tyrosine kinase activity of Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
input[SimpleEntity:113592] ATP [cytosol]
[Complex:202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:202415] Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
modified[InstanceEdit:202491] Garapati, P V, 2007-10-30 16:01:01
[InstanceEdit:202575] Garapati, P V, 2007-11-05 13:30:53
[InstanceEdit:203461] de Bono, B, 2007-11-13 13:42:15
[InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22
[InstanceEdit:204115] de Bono, B, 2007-11-25 09:35:47
[InstanceEdit:212474] Garapati, P V, 2008-02-12 09:52:01
[InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16
[InstanceEdit:213436] Garapati, P V, 2008-02-26 11:28:01
[InstanceEdit:214480] Garapati, P V, 2008-02-26 12:04:24
[InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivation of Lck
output[Complex:202266] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361431] R-HSA-202291.2
summation[Summation:202381] The binding of CD4/CD8 to non-polymorphic regions of MHC bri...
(hasEvent)[Pathway:202427] Phosphorylation of CD3 and TCR zeta chains [Homo sapiens]
(precedingEvent)[Reaction:202165] Phosphorylation of ITAM motifs in CD3 complexes [Homo sapiens]
[Reaction:8852200] Inactivation of LCK by PTPN22 [Homo sapiens]
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No pathways have been reviewed or authored by Activation of Lck (202291)