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Details on Person NDST1-4 N-deacetylates GlcNAc residues in heparan

Class:Id	Reaction:2022887
_displayName	NDST1-4 N-deacetylates GlcNAc residues in heparan
_doRelease	TRUE
_timestamp	2025-05-29 20:34:01
authored	[InstanceEdit:2022912] Jassal, B, 2011-12-01
catalystActivity	[CatalystActivity:2022873] N-acetylglucosamine deacetylase activity of NDSTs [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2022912] Jassal, B, 2011-12-01
crossReference	[DatabaseIdentifier:9941445] RHEA:70588
edited	[InstanceEdit:2022912] Jassal, B, 2011-12-01
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
input	[SimpleEntity:2022884] H2O [Golgi lumen] [DefinedSet:2076535] Heparan(3)-PGs [Golgi lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2022846] Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1 [LiteratureReference:2022844] Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2 [LiteratureReference:2022850] Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family [LiteratureReference:2022868] Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4
modified	[InstanceEdit:2024092] Jassal, B, 2011-12-14 [InstanceEdit:2076352] Jassal, B, 2012-01-27 [InstanceEdit:2161486] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2318608] Jassal, B, 2012-06-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2429636] Jupe, S, 2012-08-09 [InstanceEdit:2457601] Jassal, B, 2012-08-24 [InstanceEdit:9792655] D'Eustachio, Peter, 2022-05-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941449] Stephan, Ralf, 2025-03-07 [InstanceEdit:9953230] D'Eustachio, Peter, 2025-05-29
name	NDST1-4 N-deacetylates GlcNAc residues in heparan
output	[SimpleEntity:2022890] CH3COO- [Golgi lumen] [DefinedSet:2076346] Heparan(4)-PGs [Golgi lumen] [Homo sapiens]
precedingEvent	[Reaction:2076392] EXT1:EXT2 transfers GlcA to heparan [Homo sapiens] [Reaction:2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295010] R-HSA-2022887.4
summation	[Summation:2022935] The bifunctional enzymes heparan sulfate N-deacetylase/N-sul...
(hasEvent)	[Pathway:2022928] HS-GAG biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) [Homo sapiens]
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