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Query author contributions in Reactome

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Details on Person Diagram of Metabolism of Angiotensinogen to Angiotensins

Class:IdPathwayDiagram:2022529
_displayNameDiagram of Metabolism of Angiotensinogen to Angiotensins
_timestamp2025-04-09 00:40:13
created[InstanceEdit:2022530] May, B, 2011-12-01
height1017
modified[InstanceEdit:2028304] May, B, 2011-12-27
[InstanceEdit:2065361] May, B, 2012-01-21
[InstanceEdit:3063061] Gillespie, ME, 2013-02-06
[InstanceEdit:3229249] Gillespie, ME, 2013-03-26
[InstanceEdit:6788435] May, Bruce, 2015-07-21
[InstanceEdit:6788463] May, Bruce, 2015-07-21
[InstanceEdit:8852198] Jassal, Bijay, 2016-01-14
[InstanceEdit:9025931] May, Bruce, 2017-10-16
[InstanceEdit:9614946] Jassal, Bijay, 2018-07-30
[InstanceEdit:9615219] Jassal, Bijay, 2018-07-31
[InstanceEdit:9619088] Jassal, Bijay, 2018-09-14
[InstanceEdit:9695989] Jassal, Bijay, 2020-07-17
[InstanceEdit:9727399] Jassal, Bijay, 2021-04-16
[InstanceEdit:9832983] D'Eustachio, Peter, 2023-04-11
[InstanceEdit:9856116] May, Bruce, 2023-12-11
[InstanceEdit:9861526] May, Bruce, 2024-02-21
[InstanceEdit:9916377] Stephan, Ralf, 2024-07-24
[InstanceEdit:9944604] May, Bruce, 2025-04-05
[InstanceEdit:9944608] May, Bruce, 2025-04-06
[InstanceEdit:9945053] May, Bruce, 2025-04-09
representedPathway[Pathway:2022377] Metabolism of Angiotensinogen to Angiotensins [Homo sapiens]
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/> </Catalysts> <Properties> <displayName>ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="58" reactomeId="2028294" points="942 315, 942 520, 947 618" position="942 520" lineWidth="1.0"> <Inputs> <Input id="7" points="972 195" /> <Input id="70" points="969 319" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Catalysts> <Catalyst id="569" points="976 487" /> </Catalysts> <Properties> <displayName>Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="62" reactomeId="2065357" points="425 163, 515 161, 923 174" position="515 161" lineWidth="1.0"> <Inputs> <Input id="6" points="273 159" /> <Input id="44" points="371 119" /> </Inputs> <Outputs> <Output id="7" /> </Outputs> <Catalysts> <Catalyst id="64" points="470 298" /> </Catalysts> <Inhibitors> <Inhibitor id="566" points="476 122" /> </Inhibitors> <Properties> <displayName>Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="66" reactomeId="2065355" points="798 300, 794 414, 806 533" position="794 414" lineWidth="1.0"> <Inputs> <Input id="7" points="953 195" /> <Input id="70" points="969 319" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Catalysts> <Catalyst id="570" points="746 398" /> </Catalysts> <Inhibitors> <Inhibitor id="514" points="747 317" /> </Inhibitors> <Activators> <Activator id="18" points="739 415" /> </Activators> <Properties> <displayName>Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="84" reactomeId="6788411" points="618 900, 618 928, 624 977" position="618 928" lineWidth="1.0"> <Inputs> <Input id="38" points="621 834" /> <Input id="86" points="646 880" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Catalysts> <Catalyst id="571" points="509 882" /> </Catalysts> <Properties> <displayName>LVRN:Zn2+ (AQPEP:Zn2+) hydrolyzes Angiotensin-(2-8) (Angiotensin-III, AGT(25-32)) to Angiotensin-(3-8) (Angiotensin-IV, AGT(27-32))</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="97" reactomeId="6788439" points="636 899, 638 951, 630 977" position="638 951" lineWidth="1.0"> <Inputs> <Input id="38" points="624 834" /> <Input id="86" points="653 885" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Catalysts> <Catalyst id="572" points="670 949" /> </Catalysts> <Properties> <displayName>LNPEP:Zn2+ hydrolyzes Angiotensin-(2-8) (Angiotensin-III, AGT(26-32)) to Angiotensin-(3-8) (Angiotensin-IV, AGT(27-32))</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="494" reactomeId="9619024" points="172 567, 172 526, 172 468" position="172 526" lineWidth="1.0"> <Inputs> <Input id="495" points="156 572" /> <Input id="496" points="178 603" /> </Inputs> <Outputs> <Output id="573" points="190 457" /> <Output id="574" points="157 462" /> <Output id="497" points="172 410" /> </Outputs> <Catalysts> <Catalyst id="499" points="200 522" /> </Catalysts> <Properties> <displayName>CES1 trimer hydrolyses ACEI pro-drugs to ACEIs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="509" reactomeId="9619034" points="245 390, 409 389, 572 386, 592 252" position="409 389" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="497" /> </Inputs> <Outputs> <Output id="510" /> </Outputs> <Properties> <displayName>ACEIs translocate from ER lumen to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="511" reactomeId="9614933" points="658 299, 693 296" position="693 296" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="68" points="655 321" /> <Input id="512" points="646 285" /> </Inputs> <Outputs> <Output id="514" /> </Outputs> <Properties> <displayName>ACEIs bind ACE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="513" points="622 251, 615 252" position="618 251" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="512" /> </Inputs> <Outputs> <Output id="510" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="589" reactomeId="9944540" points="701 651, 702 678, 701 695" position="702 678" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="16" points="793 567" /> <Input id="599" points="692 651" /> </Inputs> <Outputs> <Output id="591" points="702 724" /> <Output id="592" points="686 699" /> </Outputs> <Properties> <displayName>AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="593" reactomeId="9944488" points="745 751, 766 756, 766 801" position="766 756" lineWidth="1.0"> <Inputs> <Input id="591" /> </Inputs> <Outputs> <Output id="594" points="747 816" /> <Output id="595" points="858 963" /> </Outputs> <Catalysts> <Catalyst id="568" points="542 581, 700 589" /> </Catalysts> <Properties> <displayName>ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="596" reactomeId="9944473" points="927 889, 926 917, 925 938" position="926 917" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="590" points="973 865" /> <Input id="33" points="916 869" /> </Inputs> <Outputs> <Output id="595" points="888 963" /> <Output id="597" points="946 948" /> </Outputs> <Properties> <displayName>AGT(25-31) is decarboxylated to yield Alamandine</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Metabolism of Angiotensinogen to Angiotensins (2022529)
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