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Details on Person Phosphorylation of PLC-gamma1

Class:Id	Reaction:202248
_displayName	Phosphorylation of PLC-gamma1
_doRelease	TRUE
_timestamp	2008-06-20 09:42:01
authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202180] protein tyrosine kinase activity of ZAP-70 and ITK tyrosine kinases [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
input	[DefinedSet:202318] PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:202392] The mechanism of phospholipase C-gamma1 regulation
modified	[InstanceEdit:202491] Garapati, P V, 2007-10-30 16:01:01 [InstanceEdit:202573] Garapati, P V, 2007-11-05 11:22:29 [InstanceEdit:202580] Garapati, P V, 2007-11-06 17:23:35 [InstanceEdit:202659] Garapati, P V, 2007-11-08 09:56:32 [InstanceEdit:202661] Garapati, P V, 2007-11-08 10:10:09 [InstanceEdit:203437] Garapati, P V, 2007-11-13 11:29:17 [InstanceEdit:203778] Garapati, P V, 2007-11-16 10:40:11 [InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22 [InstanceEdit:204115] de Bono, B, 2007-11-25 09:35:47 [InstanceEdit:212474] Garapati, P V, 2008-02-12 09:52:01 [InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16 [InstanceEdit:213445] Garapati, P V, 2008-02-26 11:38:23 [InstanceEdit:214480] Garapati, P V, 2008-02-26 12:04:24 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of PLC-gamma1
output	[DefinedSet:202193] Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:202331] Recruitment of PLC-gamma1 to SLP-76 [Homo sapiens] [Reaction:202216] Phosphorylation of SLP-76 [Homo sapiens] [Reaction:202212] Recruitment of PLC-gamma1 to LAT [Homo sapiens] [Reaction:202245] Phosphorylation of TBSMs in LAT [Homo sapiens] [Reaction:202375] Recruitment of ITK to SLP-76 [Homo sapiens] [Reaction:202216] Phosphorylation of SLP-76 [Homo sapiens]
regulatedBy	[NegativeRegulation:8866027] Negative regulation by 'CD101 [plasma membrane]'
regulationReference	[RegulationReference:9642195] Negative regulation by 'CD101 [plasma membrane]' Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism
releaseDate	2008-03-12
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360140] R-HSA-202248.5
summation	[Summation:202184] Three tyrosine residues at positions 771, 783 and 1254 in PL... [Summation:8866030] Immunoglobulin superfamily member 2 (IgSF2 or cell surface g...
(hasEvent)	[Pathway:202433] Generation of second messenger molecules [Homo sapiens]
(precedingEvent)	[Reaction:202354] Translocation of PLC-gamma1 to PIP2 [Homo sapiens] [Reaction:213406] Disassociation of PLC-gamma1 from LAT [Homo sapiens] [Reaction:213407] Disassociation of PLC-gamma1 from SLP-76 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775770] Update Tracker - [Reaction:202248] Phosphorylation of PLC-gamma1 - v78:[addSummation] [_UpdateTracker:9783335] Update Tracker - [Reaction:202248] Phosphorylation of PLC-gamma1 - v57:[addRegulator]
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