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Details on Person MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))

Class:Id	Reaction:2022396
_displayName	MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))
_doRelease	TRUE
_timestamp	2025-04-06 15:53:51
authored	[InstanceEdit:1998760] May, B, 2011-11-19
catalystActivity	[CatalystActivity:2022390] metallopeptidase activity of MME:Zn2+ [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643406] metallopeptidase activity of MME:Zn2+ [plasma membrane] Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2022406] May, B, 2011-11-29
edited	[InstanceEdit:1998760] May, B, 2011-11-19
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
input	[EntityWithAccessionedSequence:2022346] AGT(25-34) [extracellular region] [Homo sapiens] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:2022247] Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism [LiteratureReference:9727390] Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV [LiteratureReference:9727401] Structural analysis of neprilysin with various specific and potent inhibitors
modified	[InstanceEdit:2028302] May, B, 2011-12-27 [InstanceEdit:2065361] May, B, 2012-01-21 [InstanceEdit:2426577] May, B, 2012-08-06 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9727399] Jassal, Bijay, 2021-04-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856500] May, Bruce, 2023-12-19 [InstanceEdit:9944607] May, Bruce, 2025-04-06
name	MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7) Neprilysin Hydrolyzes Angiotensin I to Yield Angiotensin-(1-7)
output	[EntityWithAccessionedSequence:2022351] AGT(25-31) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:2022403] Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) [Homo sapiens] [BlackBoxEvent:1989774] Expression of AGT [Homo sapiens] [Reaction:2022382] Renin binds the Renin Receptor [Homo sapiens] [Reaction:2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) [Homo sapiens] [BlackBoxEvent:1989774] Expression of AGT [Homo sapiens] [Reaction:2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) [Homo sapiens] [BlackBoxEvent:1989774] Expression of AGT [Homo sapiens] [Reaction:2022382] Renin binds the Renin Receptor [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2426575] Joseph, J, 2012-08-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464919] R-HSA-2022396.6
summation	[Summation:2022415] Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes an...
(hasEvent)	[Pathway:2022377] Metabolism of Angiotensinogen to Angiotensins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9944473] AGT(25-31) is decarboxylated to yield Alamandine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776085] Update Tracker - [Reaction:2022396] MME:Zn2+ hydrolyses AGT(34-43) - v77:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) (2022396)