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Details on Person Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes an...
| Class:Id | Summation:2022387 |
|---|---|
| _displayName | Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes an... |
| _timestamp | 2021-04-16 13:27:45 |
| created | [InstanceEdit:2022406] May, B, 2011-11-29 |
| modified | [InstanceEdit:9727399] Jassal, Bijay, 2021-04-16 |
| text | Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes angiotensin-(1-9) (AGT(34-42)) to yield angiotensin-(1-7) (Rice et al. 2004). The hydrolysis of angiotensin-(1-9) catalyzed by neprilysin is more efficient than that catalyzed by angiotensin-converting enzyme (ACE) (Rice et al. 2004). MME is the major enzyme involved in the metabolic inactivation of a number of bioactive signaling peptides including the enkephalins, substance P, endothelin, bradykinin, atrial natriuretic factor, and the incretin hormone glucagon-like peptide 1. MME requires zinc as cofactor (Oefner et al. 2004, Oefner et al. 2007). |
| (summation) | [Reaction:2022368] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7) [Homo sapiens] |
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No pathways have been reviewed or authored by Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes an... (2022387)
