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Details on Person Inactivation of Lck by Csk

Class:Id	Reaction:202233
_displayName	Inactivation of Lck by Csk
_doRelease	TRUE
_timestamp	2008-06-20 09:42:50
authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202267] protein tyrosine kinase activity of Csk:p-PAG [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
definition
input	[Complex:202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:202290] Structure and regulation of Src family kinases [LiteratureReference:202415] Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
modified	[InstanceEdit:202575] Garapati, P V, 2007-11-05 13:30:53 [InstanceEdit:203775] Garapati, P V, 2007-11-16 10:35:36 [InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22 [InstanceEdit:204115] de Bono, B, 2007-11-25 09:35:47 [InstanceEdit:212474] Garapati, P V, 2008-02-12 09:52:01 [InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16 [InstanceEdit:213437] Garapati, P V, 2008-02-26 11:30:45 [InstanceEdit:214480] Garapati, P V, 2008-02-26 12:04:24 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inactivation of Lck by Csk
output	[Complex:202154] Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:203774] Interaction of Csk with PAG [Homo sapiens]
regulatedBy	[NegativeRegulation:6785250] Negative regulation by 'CD45,CD148 [plasma membrane]'
releaseDate	2008-03-12
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360662] R-HSA-202233.4
summation	[Summation:202194] Lck is a member of the Src family tyrosine kinases and these... [Summation:6785258] Protein tyrosine phosphatase CD45 (PTPRC) and CD148 (PTPRJ) ...
(hasEvent)	[Pathway:202427] Phosphorylation of CD3 and TCR zeta chains [Homo sapiens]
(precedingEvent)	[Reaction:202214] Dephosphorylation of Lck-pY505 by CD45 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775677] Update Tracker - [Reaction:202233] Inactivation of Lck by Csk - v78:[addSummation] [_UpdateTracker:9784477] Update Tracker - [Reaction:202233] Inactivation of Lck by Csk - v54:[addRegulator]
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No pathways have been reviewed or authored by Inactivation of Lck by Csk (202233)