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Details on Person CHST14 transfers SO4(2-) to GalNAc in dermatan or DS

Class:Id	Reaction:2022063
_displayName	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS
_doRelease	TRUE
_timestamp	2025-03-12 09:59:11
authored	[InstanceEdit:2022057] Jassal, B, 2011-11-25
catalystActivity	[CatalystActivity:2022068] dermatan 4-sulfotransferase activity of CHST14 [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2022057] Jassal, B, 2011-11-25
crossReference	[DatabaseIdentifier:9941019] RHEA:48053
edited	[InstanceEdit:2022057] Jassal, B, 2011-11-25
input	[DefinedSet:5607518] CHST14 substrates [Golgi lumen] [Homo sapiens] [SimpleEntity:741440] PAPS [Golgi lumen]
internalReviewed	[InstanceEdit:9941986] Stephan, Ralf, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:2022067] Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate [LiteratureReference:3636928] Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase [LiteratureReference:3636906] Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome
modified	[InstanceEdit:2065113] Jassal, B, 2012-01-20 [InstanceEdit:2065265] Jassal, B, 2012-01-20 [InstanceEdit:2161486] Jassal, B, 2012-03-14 [InstanceEdit:2161487] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:3465612] Jassal, Bijay, 2013-05-17 [InstanceEdit:3595171] Jassal, B, 2013-05-21 [InstanceEdit:3621807] Jassal, B, 2013-05-24 [InstanceEdit:3636876] Jassal, B, 2013-05-29 [InstanceEdit:5607104] Jassal, Bijay, 2014-07-11 [InstanceEdit:5607514] Jassal, Bijay, 2014-07-11 [InstanceEdit:5607551] Jassal, Bijay, 2014-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941068] Stephan, Ralf, 2025-03-07 [InstanceEdit:9941987] Stephan, Ralf, 2025-03-12 [InstanceEdit:9941990] Stephan, Ralf, 2025-03-12
name	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS GalNAc is sulfated on position 4 of GalNAc in dermatan or dermatan sulfate
output	[SimpleEntity:742343] PAP [Golgi lumen] [DefinedSet:5607524] CHST14 products [Golgi lumen] [Homo sapiens] [SimpleEntity:425969] H+ [Golgi lumen]
precedingEvent	[Reaction:2022061] Dermatan sulfate can be further sulfated on position 2 of iduronate [Homo sapiens] [Reaction:2022052] DSE converts GlcA to IdoA [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens] [Reaction:2022063] CHST14 transfers SO4(2-) to GalNAc in dermatan or DS [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens] [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS [Homo sapiens] [Reaction:2022052] DSE converts GlcA to IdoA [Homo sapiens] [Reaction:1971483] CHST11,12,13,9 transfer sulfate to (4-)GalNAc [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294803] R-HSA-2022063.3
structureModified	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
summation	[Summation:2022059] Important functional domains in dermatan or dermatan sulfate...
(hasEvent)	[Pathway:2022923] DS-GAG biosynthesis [Homo sapiens]
(normalReaction)	[FailedReaction:3636919] Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS [Homo sapiens]
(precedingEvent)	[Reaction:2022061] Dermatan sulfate can be further sulfated on position 2 of iduronate [Homo sapiens] [BlackBoxEvent:2022065] DSPGs are secreted [Homo sapiens] [Reaction:9941312] CHST15 transfers sulfate to (6-)GalNAc-4-sulfate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786016] Update Tracker - [Reaction:2022063] CHST14 transfers SO4(2-) to GalNAc in dermatan or DS - v50:[add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9787025] Update Tracker - [Reaction:2022063] CHST14 transfers SO4(2-) to GalNAc in dermatan or DS - v46:[addLiteratureReference, modifyText] [_UpdateTracker:9953636] Update Tracker - [Reaction:2022063] CHST14 transfers SO4(2-) to GalNAc in dermatan or DS - v93:[modifyText, removeLiteratureReference, removeOutput]
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