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Details on Person PLC-gamma1 plays an important role in transducing the extern...
| Class:Id | Summation:202199 |
|---|---|
| _displayName | PLC-gamma1 plays an important role in transducing the extern... |
| _timestamp | 2007-11-16 10:41:09 |
| created | [InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25 |
| modified | [InstanceEdit:202573] Garapati, P V, 2007-11-05 11:22:29 [InstanceEdit:202700] Garapati, P V, 2007-11-09 12:04:27 [InstanceEdit:203257] Garapati, P V, 2007-11-12 15:37:54 [InstanceEdit:203778] Garapati, P V, 2007-11-16 10:40:11 |
| text | PLC-gamma1 plays an important role in transducing the external signal in to second messengers by hydrolysing PIP2. PLC-gamma1 contains an N-term PH domain, a catalytic domain 'X' followed by two SH2 domains and an SH3 domain, a C-term catalytic domain 'Y' and a C2 domain (Ca++ binding). PLC-gamma1 interacts with both SLP-76 aswell as LAT. It interacts with its SH3 domain to the proline rich sequence of SLP-76. This interaction aids in localizing PLC-gamma1 to the membrane. This recruitment of PLC-gamma1 to LAT and SLP-76 is essential for its TCR induced tyrosine phosphorylation and activation. |
| (summation) | [Reaction:202331] Recruitment of PLC-gamma1 to SLP-76 [Homo sapiens] |
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No pathways have been reviewed or authored by PLC-gamma1 plays an important role in transducing the extern... (202199)
