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Details on Person SLP-76 is an adaptor protein that links proximal and distal ...
| Class:Id | Summation:202189 |
|---|---|
| _displayName | SLP-76 is an adaptor protein that links proximal and distal ... |
| _timestamp | 2007-11-16 10:41:25 |
| created | [InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25 |
| modified | [InstanceEdit:202700] Garapati, P V, 2007-11-09 12:04:27 [InstanceEdit:203257] Garapati, P V, 2007-11-12 15:37:54 [InstanceEdit:203778] Garapati, P V, 2007-11-16 10:40:11 |
| text | SLP-76 is an adaptor protein that links proximal and distal T cell receptor signaling events through its function as a molecular scaffold in the assembly of multi molecular signaling complexes. SLP-76 consists of three domains that mediate interactions with many different signaling proteins: an N-terminal acidic domain containing three tyrosine phosphorylation sites, a large central proline-rich region, and a C-terminal SH2 domain. The function of SLP-76 is dependent on its association with Gads. SLP-76 constitutively binds through its 'RxxK' motif in the proline rich region to the SH3 domain of Gads upon TCR activation. |
| (summation) | [Reaction:202241] Recruitment of SLP-76 to Gads [Homo sapiens] |
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No pathways have been reviewed or authored by SLP-76 is an adaptor protein that links proximal and distal ... (202189)
