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Details on Person Phosphorylation of ZAP-70 by Lck

Class:Id	Reaction:202168
_displayName	Phosphorylation of ZAP-70 by Lck
_doRelease	TRUE
_timestamp	2008-06-20 09:39:18
authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202370] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
input	[Complex:202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:202361] The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes [LiteratureReference:202253] The Syk family of protein tyrosine kinases in T-cell activation and development
modified	[InstanceEdit:202491] Garapati, P V, 2007-10-30 16:01:01 [InstanceEdit:202577] Garapati, P V, 2007-11-06 17:12:40 [InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22 [InstanceEdit:204115] de Bono, B, 2007-11-25 09:35:47 [InstanceEdit:212474] Garapati, P V, 2008-02-12 09:52:01 [InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16 [InstanceEdit:213465] Garapati, P V, 2008-02-26 11:41:51 [InstanceEdit:214480] Garapati, P V, 2008-02-26 12:04:24 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of ZAP-70 by Lck
output	[Complex:202345] phospho tyrosine ZAP-70 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:202344] Recruitment of ZAP-70 to phosphorylated ITAMs [Homo sapiens] [Reaction:202165] Phosphorylation of ITAM motifs in CD3 complexes [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358412] R-HSA-202168.2
summation	[Summation:202337] In ZAP-70 there are multiple phosphorylation sites (Y292, Y3...
(hasEvent)	[Pathway:202430] Translocation of ZAP-70 to Immunological synapse [Homo sapiens]
(precedingEvent)	[Reaction:202174] Activation of ZAP-70 [Homo sapiens] [Reaction:8855381] PTPN22 dephosphorylates ZAP70 [Homo sapiens] [Reaction:9793143] PTPN22 dephosphorylates NLRP3 at Y861 [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylation of ZAP-70 by Lck (202168)