Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Phosphorylation of ITAM motifs in CD3 complexes

Class:IdReaction:202165
_displayNamePhosphorylation of ITAM motifs in CD3 complexes
_doReleaseTRUE
_timestamp2012-11-21 23:17:02
authored[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity[CatalystActivity:202294] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[Complex:202266] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:202217] T cell receptor signaling: beyond complex complexes
[LiteratureReference:212485] T-cell signalling and immune system disorders
modified[InstanceEdit:202491] Garapati, P V, 2007-10-30 16:01:01
[InstanceEdit:203492] Garapati, P V, 2007-11-13 17:32:15
[InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22
[InstanceEdit:203967] de Bono, B, 2007-11-21 19:55:47
[InstanceEdit:204115] de Bono, B, 2007-11-25 09:35:47
[InstanceEdit:212474] Garapati, P V, 2008-02-12 09:52:01
[InstanceEdit:212486] Garapati, P V, 2008-02-12 11:49:39
[InstanceEdit:213345] Gopinathrao, G, 2008-02-25 21:36:16
[InstanceEdit:213445] Garapati, P V, 2008-02-26 11:38:23
[InstanceEdit:214480] Garapati, P V, 2008-02-26 12:04:24
[InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06
[InstanceEdit:2648974] D'Eustachio, P, 2012-11-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePhosphorylation of ITAM motifs in CD3 complexes
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358331] R-HSA-202165.2
summation[Summation:202232] The autophosphorylated, active Lck is now proximally positio...
(hasEvent)[Pathway:202427] Phosphorylation of CD3 and TCR zeta chains [Homo sapiens]
(precedingEvent)[Reaction:202344] Recruitment of ZAP-70 to phosphorylated ITAMs [Homo sapiens]
[Reaction:389755] Dephosphorylation of CD3-zeta by CTLA-4 bound SHP-2 [Homo sapiens]
[Reaction:389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases [Homo sapiens]
[Reaction:9942108] Phoshorylation of CD6 by CD3-TCR complex [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Phosphorylation of ITAM motifs in CD3 complexes (202165)
Follow Reactome