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Details on Person Phosphorylation of the ITAMs by Lck is followed by the recru...
| Class:Id | Summation:202149 |
|---|---|
| _displayName | Phosphorylation of the ITAMs by Lck is followed by the recru... |
| _timestamp | 2007-11-16 10:41:22 |
| created | [InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25 |
| modified | [InstanceEdit:202700] Garapati, P V, 2007-11-09 12:04:27 [InstanceEdit:203778] Garapati, P V, 2007-11-16 10:40:11 |
| text | Phosphorylation of the ITAMs by Lck is followed by the recruitment of the ZAP-70 a member of Syk family PTK, to the receptor complex. ZAP-70 is exclusively expressed in T cells and NK cells. The dually phosphorylated ITAMs provide a high-affinity docking site for the tandem SH2-domains of the ZAP-70. Once recruited, ZAP-70 is activated by phosphorylation and will be responsible for the phosphorylation of further downstream molecules. Due to the presence of 10 ITAMs in the TCR complex, up to 10 ZAP-70 molecules may cluster on the fully phosphorylated receptors. |
| (summation) | [Reaction:202344] Recruitment of ZAP-70 to phosphorylated ITAMs [Homo sapiens] |
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No pathways have been reviewed or authored by Phosphorylation of the ITAMs by Lck is followed by the recru... (202149)
