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Details on Person AKT1 binds eNOS complex via HSP90

Class:Id	Reaction:202137
_displayName	AKT1 binds eNOS complex via HSP90
_doRelease	TRUE
_timestamp	2024-08-02 15:41:30
authored	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
catalystActivity	[CatalystActivity:9911126] enzyme-substrate adaptor activity of eNOS:CaM:HSP90 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9911172] enzyme-substrate adaptor activity of eNOS:CaM:HSP90 [plasma membrane] Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
input	[Complex:202105] eNOS:CaM:HSP90 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9911325] D'Eustachio, Peter, 2024-05-28
literatureReference	[LiteratureReference:202142] Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release [LiteratureReference:203755] Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex
modified	[InstanceEdit:202146] Hemish, J, 2007-10-19 18:29:27 [InstanceEdit:203590] Hemish, J, 2007-11-15 17:00:52 [InstanceEdit:204294] Gopinathrao, G, 2007-11-27 21:50:36 [InstanceEdit:212984] Gopinathrao, G, 2008-02-16 13:08:05 [InstanceEdit:213341] Gopinathrao, G, 2008-02-25 19:53:36 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:215281] Gopinathrao, G, 2008-02-28 04:43:00 [InstanceEdit:215295] Gopinathrao, G, 2008-02-28 05:37:31 [InstanceEdit:215431] Gopinathrao, G, 2008-02-28 15:47:21 [InstanceEdit:215471] Gopinathrao, G, 2008-02-28 17:53:21 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1497774] Jassal, B, 2011-08-17 [InstanceEdit:5357492] Garapati, P V, 2014-03-21 [InstanceEdit:8864975] Jupe, Steve, 2016-03-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24 [InstanceEdit:9911326] D'Eustachio, Peter, 2024-05-28 [InstanceEdit:9917332] D'Eustachio, Peter, 2024-08-02
name	AKT1 binds eNOS complex via HSP90
output	[Complex:202113] eNOS:CaM:HSP90:p-AKT1 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:202132] depalmitoylated eNOS translocates from plasma membrane [Homo sapiens] [Reaction:203613] Depalmitoylation of eNOS [Homo sapiens] [Reaction:202144] Caveolin-1 dissociates from eNOS:CaM:HSP90 complex [Homo sapiens] [Reaction:202129] HSP90 binds eNOS:Caveolin-1:CaM complex [Homo sapiens] [Reaction:198270] PDPK1 phosphorylates AKT at T308 [Homo sapiens] [Reaction:2317314] AKT binds PDPK1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-03-12
reviewed	[InstanceEdit:215470] Enikolopov, G, 2008-02-28 17:52:44 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358450] R-HSA-202137.4
structureModified	[InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24
summation	[Summation:203559] AKT1 is recruited to the M domain of HSP90 (Fontana et al. 2...
(hasEvent)	[Pathway:203615] eNOS activation [Homo sapiens] [Pathway:5218920] VEGFR2 mediated vascular permeability [Homo sapiens]
(precedingEvent)	[Reaction:202111] AKT1 phosphorylates eNOS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789074] Update Tracker - [Reaction:202137] AKT1 binds eNOS complex via HSP90 - v38:[modifyText] [_UpdateTracker:9919438] Update Tracker - [Reaction:202137] AKT1 binds eNOS complex via HSP90 - v90:[modifyText, removeCatalystActivity]
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