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Details on Person HSP90 binds eNOS:Caveolin-1:CaM complex
Class:Id Reaction:202129
_displayName HSP90 binds eNOS:Caveolin-1:CaM complex
_doRelease TRUE
_timestamp 2024-08-02 15:43:25
authored [InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
catalystActivity [CatalystActivity:9911140] nitric-oxide synthase regulator activity of HSP90AA1 [cytosol]
catalystActivityReference [CatalystActivityReference:9911153] nitric-oxide synthase regulator activity of HSP90AA1 [cytosol] Dynamic activation of endothelial nitric oxide synthase by Hsp90
compartment [Compartment:70101] cytosol [Compartment:876] plasma membrane
created [InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
input [EntityWithAccessionedSequence:192864] HSP90AA1 [cytosol] [Homo sapiens] [Complex:202116] eNOS:Caveolin-1:CaM [plasma membrane] [Homo sapiens]
internalReviewed [InstanceEdit:9911325] D'Eustachio, Peter, 2024-05-28
literatureReference [LiteratureReference:202143] Dynamic activation of endothelial nitric oxide synthase by Hsp90
modified [InstanceEdit:202146] Hemish, J, 2007-10-19 18:29:27 [InstanceEdit:203590] Hemish, J, 2007-11-15 17:00:52 [InstanceEdit:204294] Gopinathrao, G, 2007-11-27 21:50:36 [InstanceEdit:212984] Gopinathrao, G, 2008-02-16 13:08:05 [InstanceEdit:213341] Gopinathrao, G, 2008-02-25 19:53:36 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:215281] Gopinathrao, G, 2008-02-28 04:43:00 [InstanceEdit:215295] Gopinathrao, G, 2008-02-28 05:37:31 [InstanceEdit:215431] Gopinathrao, G, 2008-02-28 15:47:21 [InstanceEdit:215471] Gopinathrao, G, 2008-02-28 17:53:21 [InstanceEdit:534991] D'Eustachio, P, 2010-03-03 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24 [InstanceEdit:9911326] D'Eustachio, Peter, 2024-05-28 [InstanceEdit:9917335] D'Eustachio, Peter, 2024-08-02
name HSP90 binds eNOS:Caveolin-1:CaM complex
output [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens] [Complex:202130] eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus [ReviewStatus:9821385] four stars
releaseDate 2008-03-12
reviewed [InstanceEdit:215470] Enikolopov, G, 2008-02-28 17:52:44 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:358547] R-HSA-202129.3
structureModified [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24
summation [Summation:203744] HSP90 interacts with the amino terminus of eNOS (amino acids...
(hasEvent) [Pathway:203615] eNOS activation [Homo sapiens] [Pathway:5218920] VEGFR2 mediated vascular permeability [Homo sapiens]
(precedingEvent) [Reaction:202144] Caveolin-1 dissociates from eNOS:CaM:HSP90 complex [Homo sapiens] [NegativePrecedingEvent:9865999] Futile Cycle: HSP90 binds eNOS:Caveolin-1:CaM complex
(updatedInstance) [_UpdateTracker:9790386] Update Tracker - [Reaction:202129] HSP90 binds eNOS:Caveolin-1:CaM complex - v33:[add_removeOutput] [_UpdateTracker:9919512] Update Tracker - [Reaction:202129] HSP90 binds eNOS:Caveolin-1:CaM complex - v90:[removeCatalystActivity]
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