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Details on Person AKT1 phosphorylates eNOS

Class:Id	Reaction:202111
_displayName	AKT1 phosphorylates eNOS
_doRelease	TRUE
_timestamp	2024-08-02 15:41:34
authored	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
catalystActivity	[CatalystActivity:9911152] protein serine/threonine kinase activity of eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9911161] protein serine/threonine kinase activity of eNOS:CaM:HSP90:p-AKT1 [plasma membrane] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
crossReference	[DatabaseIdentifier:9857128] RHEA:17990
input	[Complex:202113] eNOS:CaM:HSP90:p-AKT1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9911325] D'Eustachio, Peter, 2024-05-28
literatureReference	[LiteratureReference:202117] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation [LiteratureReference:202125] Regulation of endothelium-derived nitric oxide production by the protein kinase Akt [LiteratureReference:202138] The Akt kinase signals directly to endothelial nitric oxide synthase
modified	[InstanceEdit:202146] Hemish, J, 2007-10-19 18:29:27 [InstanceEdit:203590] Hemish, J, 2007-11-15 17:00:52 [InstanceEdit:204294] Gopinathrao, G, 2007-11-27 21:50:36 [InstanceEdit:212984] Gopinathrao, G, 2008-02-16 13:08:05 [InstanceEdit:213341] Gopinathrao, G, 2008-02-25 19:53:36 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:215281] Gopinathrao, G, 2008-02-28 04:43:00 [InstanceEdit:215294] Gopinathrao, G, 2008-02-28 05:36:31 [InstanceEdit:215431] Gopinathrao, G, 2008-02-28 15:47:21 [InstanceEdit:215471] Gopinathrao, G, 2008-02-28 17:53:21 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1497774] Jassal, B, 2011-08-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24 [InstanceEdit:9911326] D'Eustachio, Peter, 2024-05-28 [InstanceEdit:9917332] D'Eustachio, Peter, 2024-08-02
name	AKT1 phosphorylates eNOS ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)
output	[Complex:202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:202137] AKT1 binds eNOS complex via HSP90 [Homo sapiens] [BlackBoxEvent:202132] depalmitoylated eNOS translocates from plasma membrane [Homo sapiens] [Reaction:202144] Caveolin-1 dissociates from eNOS:CaM:HSP90 complex [Homo sapiens] [Reaction:198270] PDPK1 phosphorylates AKT at T308 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-03-12
reviewed	[InstanceEdit:215470] Enikolopov, G, 2008-02-28 17:52:44 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359408] R-HSA-202111.3
structureModified	[InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24
summation	[Summation:202115] HSP90 serves as a scaffold to promote productive interaction...
(hasEvent)	[Pathway:203615] eNOS activation [Homo sapiens] [Pathway:5218920] VEGFR2 mediated vascular permeability [Homo sapiens]
(precedingEvent)	[Reaction:1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789484] Update Tracker - [Reaction:202111] AKT1 phosphorylates eNOS - v38:[modifyText] [_UpdateTracker:9919403] Update Tracker - [Reaction:202111] AKT1 phosphorylates eNOS - v90:[modifyText, removeCatalystActivity, removeOutput]
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