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Details on Person eNOS:Caveolin-1 complex binds to CaM

Class:Id	Reaction:202110
_displayName	eNOS:Caveolin-1 complex binds to CaM
_doRelease	TRUE
_timestamp	2024-08-02 15:43:45
authored	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
catalystActivity	[CatalystActivity:9911146] calmodulin binding activity of eNOS:Caveolin-1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9911156] calmodulin binding activity of eNOS:Caveolin-1 [plasma membrane] Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
input	[Complex:202128] eNOS:Caveolin-1 [plasma membrane] [Homo sapiens] [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens] [Complex:74294] CALM1:4xCa2+ [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9911325] D'Eustachio, Peter, 2024-05-28
literatureReference	[LiteratureReference:203731] Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide [LiteratureReference:203752] Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin
modified	[InstanceEdit:202146] Hemish, J, 2007-10-19 18:29:27 [InstanceEdit:203590] Hemish, J, 2007-11-15 17:00:52 [InstanceEdit:204147] Hemish, J, 2007-11-26 15:35:30 [InstanceEdit:204294] Gopinathrao, G, 2007-11-27 21:50:36 [InstanceEdit:212984] Gopinathrao, G, 2008-02-16 13:08:05 [InstanceEdit:213341] Gopinathrao, G, 2008-02-25 19:53:36 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:215281] Gopinathrao, G, 2008-02-28 04:43:00 [InstanceEdit:215295] Gopinathrao, G, 2008-02-28 05:37:31 [InstanceEdit:215431] Gopinathrao, G, 2008-02-28 15:47:21 [InstanceEdit:215471] Gopinathrao, G, 2008-02-28 17:53:21 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866007] Orlic-Milacic, Marija, 2024-03-20 [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24 [InstanceEdit:9911326] D'Eustachio, Peter, 2024-05-28 [InstanceEdit:9917335] D'Eustachio, Peter, 2024-08-02
name	eNOS:Caveolin-1 complex binds to CaM
negativePrecedingEvent	[NegativePrecedingEvent:9865999] Futile Cycle: HSP90 binds eNOS:Caveolin-1:CaM complex
output	[Complex:202116] eNOS:Caveolin-1:CaM [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:203712] eNOS associates with Caveolin-1 [Homo sapiens] [BlackBoxEvent:203700] eNOS translocation from Golgi to Caveolae [Homo sapiens] [Reaction:74448] Calcium binds calmodulin [Homo sapiens] [Reaction:139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol [Homo sapiens] [Reaction:434798] CRAC translocates calcium from the extracellular region to the cytosol [Homo sapiens] [Reaction:2089943] TRPC1 translocates calcium from the extracellular region to the cytosol [Homo sapiens] [Reaction:9700718] T-type VDCC transports Ca2+ from extracellular region to cytosol [Homo sapiens] [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol [Homo sapiens] [Reaction:9858800] TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-03-12
reviewed	[InstanceEdit:215470] Enikolopov, G, 2008-02-28 17:52:44 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358250] R-HSA-202110.4
structureModified	[InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24
summation	[Summation:203540] Caveolin inhibition of eNOS is relieved by calmodulin, the f...
(hasEvent)	[Pathway:203615] eNOS activation [Homo sapiens] [Pathway:5218920] VEGFR2 mediated vascular permeability [Homo sapiens]
(precedingEvent)	[Reaction:202129] HSP90 binds eNOS:Caveolin-1:CaM complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919377] Update Tracker - [Reaction:202110] eNOS:Caveolin-1 complex binds to CaM - v90:[modifyText, removeCatalystActivity, removeLiteratureReference]
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No pathways have been reviewed or authored by eNOS:Caveolin-1 complex binds to CaM (202110)