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Details on Person TOCA-1 mediated release of the inhibition of N-WASP by WIP

Class:Id	Reaction:202008
_displayName	TOCA-1 mediated release of the inhibition of N-WASP by WIP
_doRelease	FALSE
_timestamp	2016-07-15 23:50:48
authored	[InstanceEdit:201902] Pollard, T, 2007-09-30 10:07:47
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:202009] Matthews, L, 2007-10-09 13:46:18
inferredFrom	[Reaction:203067] **Xenopus Bovine reaction
input	[EntityWithAccessionedSequence:202991] FNBP1L-1 [plasma membrane] [Homo sapiens] [Complex:203039] WIP:N-WASP:PIP2:Cdc42-GTP complex [plasma membrane] [Homo sapiens]
modified	[InstanceEdit:203114] Matthews, L, 2007-11-12 14:43:19 [InstanceEdit:203407] Matthews, L, 2007-11-12 23:29:54 [InstanceEdit:203953] Gopinathrao, G, 2007-11-20 17:54:44 [InstanceEdit:204193] Matthews, L, 2007-11-26 21:17:31 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	TOCA-1 mediated release of the inhibition of N-WASP by WIP
output	[Complex:202990] TOCA-1:(Cdc42-GTP):PIP2:N-WASP:WIP complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:203068] Association of activated Cdc42 and PIP2 with WIP:N-WASP [Homo sapiens] [Reaction:203046] WIP binds N-WASP [Homo sapiens] [Reaction:203066] Activation of Cdc24 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8928911] R-HSA-202008.1
summation	[Summation:202004] Evidence suggests that WASP and N-WASP exist in an inactive ...
(hasEvent)	[Pathway:202026] Cdc42/PIP2 mediated activation of N-WASP [Homo sapiens]
(precedingEvent)	[Reaction:201888] Association of TOCA-1 activated N-WASP with Arp2/3 complex results in activation of Arp2/3 and initiatiation of a new actin filament
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