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Details on Person Evidence suggests that WASP and N-WASP exist in an inactive ...
| Class:Id | Summation:202004 |
|---|---|
| _displayName | Evidence suggests that WASP and N-WASP exist in an inactive ... |
| _timestamp | 2007-11-26 12:46:46 |
| created | [InstanceEdit:202009] Matthews, L, 2007-10-09 13:46:18 |
| literatureReference | [LiteratureReference:202984] Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate [LiteratureReference:196701] Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex |
| modified | [InstanceEdit:202983] Matthews, L, 2007-11-12 14:29:22 [InstanceEdit:204124] Matthews, L, 2007-11-26 12:46:43 |
| text | Evidence suggests that WASP and N-WASP exist in an inactive auto-inhibited conformation in resting cells as a result of intramolecular interactions between the VCA domain and the GBD domain and the basic region upstream of the GBD (Rohatgi et al.2000). WASP and N-WASP are activated in vitro following binding of active Cdc42. In Xenopus, TOCA-1, which binds both Cdc42 and N-WASP, relieves WIP-mediated inhibition and enables Cdc42 activation of the N-WASP–WIP complex (Ho et al., 2004). Cdc42–GTP is required for the activation of N-WASP and for TOCA-1 to bind to the N-WASP–WIP complex and activate it. **Inferred from reaction involving bovine TOCA-1, ARP2/3, Xenopus N-WASP-WIP complex. |
| (summation) | [Reaction:202008] TOCA-1 mediated release of the inhibition of N-WASP by WIP [Homo sapiens] |
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No pathways have been reviewed or authored by Evidence suggests that WASP and N-WASP exist in an inactive ... (202004)
