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Details on Person UniProt:Q14247 CTTN
| Class:Id | ReferenceGeneProduct:201900 |
|---|---|
| _chainChangeLog | chain:1-550 added on Sat February 7 2015 |
| _displayName | UniProt:Q14247 CTTN |
| _timestamp | 2024-11-03 20:12:13 |
| chain | chain:1-550 |
| checksum | 7799326C2B4383BB |
| comment | FUNCTION Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290).SUBUNIT Part of a complex composed of NEDD9, AURKA and CTTN; within the complex NEDD9 acts as a scaffold protein and is required for complex formation (PubMed:24574519). Interacts (via N-terminus) with NEDD9 (PubMed:24574519). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Forms a complex made of ABL1 and MYLK (PubMed:20861316). Interacts with SHANK2 and SHANK3 (via its SH3 domain). Interacts with FGD1. Interacts with ABL2 (By similarity). Interacts with KCNA2 (via non-phosphorylated C-terminus) (PubMed:12151401). Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1 (via Pro-rich region). Interacts (via SH3 domain) with DNM2 (By similarity). Interacts with ACTN1 (By similarity). Interacts with FER (PubMed:9722593). Interacts with CTTNBP2NL; this interaction may target CTTN to stress fibers. Interacts with CTTNBP2; this interaction may target CTTN at the cell cortex or dendritic spines. Interacts with KCNH1 (PubMed:23144454). Interacts (via SH3 domain) with DIP2A (via N-terminus); the interaction enhances CTTN acetylation and is required for proper synaptic transmission (By similarity). Interacts with XIRP1 (via N-terminus); the interaction promotes CTTN localization to intercalated disks in cardiomyocytes (By similarity).INTERACTION Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity).ALTERNATIVE PRODUCTS The SH3 motif may mediate binding to the cytoskeleton.PTM Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.PTM Acetylated.ONLINE INFORMATION Cortactin entry |
| created | [InstanceEdit:201903] Matthews, L, 2007-10-02 06:58:48 |
| description | recommendedName: Src substrate cortactin alternativeName: Amplaxin alternativeName: Oncogene EMS1 |
| geneName | CTTN EMS1 |
| identifier | Q14247 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell junction Cell membrane Cell projection Coated pit Coiled coil Cytoplasm Cytoskeleton Endocytosis Endoplasmic reticulum Isopeptide bond Membrane Methylation Phosphoprotein Proteomics identification Reference proteome Repeat SH3 domain Synapse Ubl conjugation |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CTTN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989842] ENSEMBL:ENSG00000085733 CTTN [Homo sapiens] |
| secondaryIdentifier | SRC8_HUMAN Q8N707 Q96H99 |
| sequenceLength | 550 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971679] UniProt:Q14247-1 CTTN [Homo sapiens] [ReferenceIsoform:8971680] UniProt:Q14247-2 CTTN [Homo sapiens] [ReferenceIsoform:8971681] UniProt:Q14247-3 CTTN [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201894] CTTN [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:419962] p-Y421,Y466,Y482-CTTN [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:442842] p-S113-CTTN [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:419931] O4'-phospho-L-tyrosine at 466 [ModifiedResidue:419948] O4'-phospho-L-tyrosine at 482 [ModifiedResidue:419959] O4'-phospho-L-tyrosine at 421 [ModifiedResidue:442845] O-phospho-L-serine at 113 |
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No pathways have been reviewed or authored by UniProt:Q14247 CTTN (201900)
