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Details on Person Arp2/3 complexes bind to the side of the mother filament and...
| Class:Id | Summation:201891 |
|---|---|
| _displayName | Arp2/3 complexes bind to the side of the mother filament and... |
| _timestamp | 2007-11-12 14:33:59 |
| created | [InstanceEdit:201903] Matthews, L, 2007-10-02 06:58:48 |
| literatureReference | [LiteratureReference:201885] Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor |
| modified | [InstanceEdit:203059] Matthews, L, 2007-11-12 14:33:52 |
| text | Arp2/3 complexes bind to the side of the mother filament and the pointed end of the daughter filament that it nucleates. These interactions result in a y-branch with an angle of approximately 70 degree between the mother and daughter filaments. Nucleotide binding to the Arp2 and Arp3 subunits is essential for Arp2/3 complex activity and is coupled to binding of the nucleation promoting factor (NPF). The binding of WASP protein family NPFs to the ARP2/3 complex induces further conformational reorganization that is is critical for its activation. (Goley et al., 2004). |
| (summation) | [Reaction:201888] Association of TOCA-1 activated N-WASP with Arp2/3 complex results in activation of Arp2/3 and initiatiation of a new actin filament |
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No pathways have been reviewed or authored by Arp2/3 complexes bind to the side of the mother filament and... (201891)
