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Details on Person DARPP-32 is dephosphorylated on Thr75 by PP2A

Class:Id	Reaction:201790
_displayName	DARPP-32 is dephosphorylated on Thr75 by PP2A
_doRelease	TRUE
_timestamp	2008-12-03 09:56:38
authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:201794] protein serine/threonine phosphatase activity of PP2A-ABdeltaC complex [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201796] Jassal, Bijay, 2007-09-20
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
input	[DefinedSet:180026] p-T75-DARPP32s [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:375181] The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A [LiteratureReference:375548] Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A
modified	[InstanceEdit:202045] Jassal, B, 2007-10-16 11:53:54 [InstanceEdit:375190] Jassal, B, 2008-08-12 10:20:08 [InstanceEdit:375567] Jassal, B, 2008-09-04 10:46:07 [InstanceEdit:379936] Jassal, Bijay, 2008-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DARPP-32 is dephosphorylated on Thr75 by PP2A
output	[DefinedSet:180044] DARPP-32 (for CDK5 phosphorylation) [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:180047] CDK5 phosphorylates DARPP-32 on Thr75 [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387702] R-HSA-201790.2
summation	[Summation:375185] PP2A is ubiquitously expressed in eukaryotic cells, existing...
(hasEvent)	[Pathway:180024] DARPP-32 events [Homo sapiens]
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