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Details on Person Beta-catenin:TCF associates with BCL9 and PYGO
Class:Id Reaction:201712 _displayName Beta-catenin:TCF associates with BCL9 and PYGO _doRelease TRUE _timestamp 2025-08-29 19:55:16 authored [InstanceEdit:4415000] Rothfels, K, 2013-08-23 compartment [Compartment:7660] nucleoplasm created [InstanceEdit:201703] Matthews, L, 2007-09-10 21:56:08 edited [InstanceEdit:4655138] Gillespie, ME, 2013-10-02 input [DefinedSet:3305844] BCL9 [nucleoplasm] [Homo sapiens] [DefinedSet:3322379] PYGO [nucleoplasm] [Homo sapiens] [Complex:3299548] TCF/LEF:CTNNB1 [nucleoplasm] [Homo sapiens] literatureReference [LiteratureReference:208112] Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex [LiteratureReference:3305822] Crystal structure of a beta-catenin/BCL9/Tcf4 complex [LiteratureReference:3305750] Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21 [LiteratureReference:3305839] The many faces and functions of ?-catenin [LiteratureReference:3305789] Pygopus and the Wnt signaling pathway: a diverse set of connections [LiteratureReference:3305731] pygopus Encodes a nuclear protein essential for wingless/Wnt signaling [LiteratureReference:3305798] A new nuclear component of the Wnt signalling pathway [LiteratureReference:3305760] Probing transcription-specific outputs of ?-catenin in vivo [LiteratureReference:3305777] Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation [LiteratureReference:208361] Identification and in vivo role of the Armadillo-Legless interaction [LiteratureReference:3305793] Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin [LiteratureReference:208104] Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins [LiteratureReference:3305733] pygopus 2 has a crucial, Wnt pathway-independent function in lens induction [LiteratureReference:3305767] Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development [LiteratureReference:3305838] Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2 [LiteratureReference:3305816] Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin [LiteratureReference:3305830] Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex [LiteratureReference:3305788] The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 [LiteratureReference:3305795] Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells [LiteratureReference:3322328] The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes modified [InstanceEdit:201918] Matthews, L, 2007-10-09 12:26:21 [InstanceEdit:2981021] Jassal, B, 2013-01-14 [InstanceEdit:3305853] Rothfels, K, 2013-04-24 [InstanceEdit:3322437] Rothfels, K, 2013-05-03 [InstanceEdit:3364044] Rothfels, K, 2013-05-13 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518479] Rothfels, K, 2013-09-03 [InstanceEdit:4655190] Rothfels, K, 2013-10-02 [InstanceEdit:5097337] Rothfels, K, 2013-11-11 [InstanceEdit:5146697] Rothfels, K, 2013-11-18 [InstanceEdit:5251649] Rothfels, K, 2014-02-04 [InstanceEdit:5323630] Rothfels, K, 2014-02-15 [InstanceEdit:5333083] Rothfels, K, 2014-02-18 [InstanceEdit:5576960] Rothfels, Karen, 2014-05-27 [InstanceEdit:6782938] Rothfels, Karen, 2015-06-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9965547] Orlic-Milacic, Marija, 2025-08-29 name Beta-catenin:TCF associates with BCL9 and PYGO negativePrecedingEvent [NegativePrecedingEvent:9965525] Futile Cycle: APC promotes disassembly of beta-catenin transactivation complex output [Complex:201917] TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] [Homo sapiens] precedingEvent
releaseDate 2014-03-12 reviewed [InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:5644407] R-HSA-201712.4 summation [Summation:3305848] Once tethered at WNT promoters, beta-catenin is a scaffold f... (hasEvent) [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex [Homo sapiens] (precedingEvent) [Reaction:3364014] Recruitment of MLL2 methyltransferase complex [Homo sapiens]
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