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Details on Person Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
Class:Id Reaction:201677 _displayName Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta _doRelease TRUE _timestamp 2015-06-09 17:58:00 authored [InstanceEdit:4415000] Rothfels, K, 2013-08-23 catalystActivity [CatalystActivity:1505507] protein serine/threonine kinase activity of WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region created [InstanceEdit:201703] Matthews, L, 2007-09-10 21:56:08 edited [InstanceEdit:201697] Matthews, L, 2007-09-10 12:45:35 [InstanceEdit:4655138] Gillespie, ME, 2013-10-02 input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:1504184] WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] [Homo sapiens] literatureReference [LiteratureReference:208343] A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation [LiteratureReference:208147] A mechanism for Wnt coreceptor activation [LiteratureReference:1458899] Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6 [LiteratureReference:1458867] LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way modified [InstanceEdit:1458922] Rothfels, K, 2011-07-22 [InstanceEdit:2130743] Rothfels, K, 2012-02-21 [InstanceEdit:3774851] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518452] Rothfels, K, 2013-09-03 [InstanceEdit:4641294] Rothfels, K, 2013-09-27 [InstanceEdit:4655210] Rothfels, K, 2013-10-02 [InstanceEdit:5097360] Rothfels, K, 2013-11-11 [InstanceEdit:5146685] Rothfels, K, 2013-11-18 [InstanceEdit:5228766] Rothfels, K, 2014-01-14 [InstanceEdit:5251689] Rothfels, K, 2014-02-04 [InstanceEdit:5323651] Rothfels, K, 2014-02-15 [InstanceEdit:5576972] Rothfels, Karen, 2014-05-27 [InstanceEdit:6782926] Rothfels, Karen, 2015-06-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:1458897] WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2014-03-12 reviewed [InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:5644381] R-HSA-201677.3 summation [Summation:1458879] LRP5/6 contains 5 PPP(S/T)PxS motifs in its intracellular do... (hasEvent) [Pathway:201674] Sequential phosphorylation of Lrp5/6 cytoplasmic domain [Homo sapiens] [Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane [Homo sapiens] (precedingEvent) [Reaction:201691] Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI [Homo sapiens]
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