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Details on Person Caspase-mediated cleavage of GAS2

Class:Id	Reaction:201639
_displayName	Caspase-mediated cleavage of GAS2
_doRelease	TRUE
_timestamp	2017-11-17 22:10:44
authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
catalystActivity	[CatalystActivity:202853] cysteine-type endopeptidase activity of Caspase-3, Caspase-7 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201633] Matthews, L, 2007-09-03 08:38:43
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:201989] Matthews, L, 2007-10-09 13:44:38 [InstanceEdit:202801] Matthews, L, 2007-11-11 23:40:56
input	[EntityWithAccessionedSequence:201614] GAS2 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:202842] Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases [LiteratureReference:202885] Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis
modified	[InstanceEdit:202886] Matthews, L, 2007-11-12 10:01:04 [InstanceEdit:202979] Matthews, L, 2007-11-12 13:46:30 [InstanceEdit:204066] Matthews, L, 2007-11-23 00:38:11 [InstanceEdit:352491] Matthews, L, 2008-06-03 01:13:58 [InstanceEdit:8940243] D'Eustachio, Peter, 2016-09-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9029449] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-mediated cleavage of GAS2
output	[EntityWithAccessionedSequence:202833] GAS2(1-279) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202887] GAS2(280-313) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:114252] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens] [Reaction:114261] Cleavage of Procaspase-7 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens] [Reaction:114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 [Homo sapiens] [Reaction:114306] SMAC binds XIAP:Caspase-3 [Homo sapiens] [Reaction:114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 [Homo sapiens] [Reaction:114354] SMAC binds XIAP:Caspase-7 [Homo sapiens] [Reaction:418845] Activation of caspase-3 [Homo sapiens] [Reaction:373700] Caspase-9 binds DCC:DIP13alpha complex [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:204051] Ranganathan, S, 2007-11-23 00:10:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359326] R-HSA-201639.4
summation	[Summation:202884] Cleavage of Gas2 during apoptosis is associated with changes...
(hasEvent)	[Pathway:264870] Caspase-mediated cleavage of cytoskeletal proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782175] Update Tracker - [Reaction:201639] Caspase-mediated cleavage of GAS2 - v59:[add_removeLiteratureReference]
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