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Details on Person Caspase-mediated cleavage of plectin-1

Class:Id	Reaction:201637
_displayName	Caspase-mediated cleavage of plectin-1
_doRelease	TRUE
_timestamp	2017-11-17 22:10:48
authored	[InstanceEdit:352235] Schulze-Osthoff, K, 2008-05-18 10:00:05
catalystActivity	[CatalystActivity:139951] cysteine-type endopeptidase activity of active caspase-8 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201633] Matthews, L, 2007-09-03 08:38:43
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:349501] Matthews, L, 2008-05-08 00:38:35 [InstanceEdit:352491] Matthews, L, 2008-06-03 01:13:58
input	[EntityWithAccessionedSequence:201575] PLEC [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:350632] Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis
modified	[InstanceEdit:350634] Matthews, L, 2008-05-20 07:46:51 [InstanceEdit:352261] Matthews, L, 2008-06-02 08:00:47 [InstanceEdit:352465] Matthews, L, 2008-06-03 00:23:29 [InstanceEdit:352491] Matthews, L, 2008-06-03 01:13:58 [InstanceEdit:353177] Matthews, L, 2008-06-12 00:28:36 [InstanceEdit:9029449] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-mediated cleavage of plectin-1
output	[EntityWithAccessionedSequence:350638] PLEC(1-2395) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:350618] PLEC(2396-4684) [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:139952] Caspase-8 processing in the DISC [Homo sapiens] [Reaction:141156] TRAIL-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:141159] TNF-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:73945] FAS-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:2562564] Caspase-8 processing within TLR4 complex [Homo sapiens] [Reaction:2562541] TLR4-induced ripoptosome assembly [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359318] R-HSA-201637.3
summation	[Summation:350636] Plectin is a major cross-linking protein of the three main ...
(hasEvent)	[Pathway:264870] Caspase-mediated cleavage of cytoskeletal proteins [Homo sapiens]
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No pathways have been reviewed or authored by Caspase-mediated cleavage of plectin-1 (201637)