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Details on Person Caspase-mediated cleavage of vimentin at DSVD (85)

Class:Id	Reaction:201628
_displayName	Caspase-mediated cleavage of vimentin at DSVD (85)
_doRelease	TRUE
_timestamp	2017-11-17 22:10:49
authored	[InstanceEdit:352235] Schulze-Osthoff, K, 2008-05-18 10:00:05
catalystActivity	[CatalystActivity:202853] cysteine-type endopeptidase activity of Caspase-3, Caspase-7 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201633] Matthews, L, 2007-09-03 08:38:43
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:350341] Matthews, L, 2008-05-18 16:53:19
input	[EntityWithAccessionedSequence:201600] VIM [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:350282] Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis
modified	[InstanceEdit:350279] Matthews, L, 2008-05-18 15:14:41 [InstanceEdit:350634] Matthews, L, 2008-05-20 07:46:51 [InstanceEdit:352261] Matthews, L, 2008-06-02 08:00:47 [InstanceEdit:352491] Matthews, L, 2008-06-03 01:13:58 [InstanceEdit:353177] Matthews, L, 2008-06-12 00:28:36 [InstanceEdit:9029449] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-mediated cleavage of vimentin at DSVD (85)
output	[EntityWithAccessionedSequence:350264] VIM(2-85) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:350294] VIM(86-466) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:114252] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens] [Reaction:114261] Cleavage of Procaspase-7 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens] [Reaction:418845] Activation of caspase-3 [Homo sapiens] [Reaction:373700] Caspase-9 binds DCC:DIP13alpha complex [Homo sapiens] [Reaction:114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 [Homo sapiens] [Reaction:114306] SMAC binds XIAP:Caspase-3 [Homo sapiens] [Reaction:114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 [Homo sapiens] [Reaction:114354] SMAC binds XIAP:Caspase-7 [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358439] R-HSA-201628.3
summation	[Summation:350269] Vimentin is cleaved by several caspases during apoptosis (M...
(hasEvent)	[Pathway:264870] Caspase-mediated cleavage of cytoskeletal proteins [Homo sapiens]
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