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Details on Person Caspase-mediated cleavage of Rock-1

Class:Id	Reaction:201611
_displayName	Caspase-mediated cleavage of Rock-1
_doRelease	TRUE
_timestamp	2017-11-17 22:16:17
authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201610] Matthews, L, 2007-09-03 08:36:41
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:211656] Matthews, L, 2008-02-08 00:35:06
input	[EntityWithAccessionedSequence:212509] ROCK1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:213418] Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
modified	[InstanceEdit:212529] Matthews, L, 2008-02-12 15:50:30 [InstanceEdit:212556] Matthews, L, 2008-02-12 16:16:00 [InstanceEdit:212558] Matthews, L, 2008-02-12 16:31:27 [InstanceEdit:213425] Matthews, L, 2008-02-26 11:21:24 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9029450] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-mediated cleavage of Rock-1
output	[EntityWithAccessionedSequence:212523] ROCK1(1-1113) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:212524] ROCK1(1114-1354) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:114252] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens] [Reaction:114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 [Homo sapiens] [Reaction:114306] SMAC binds XIAP:Caspase-3 [Homo sapiens] [Reaction:418845] Activation of caspase-3 [Homo sapiens] [Reaction:373700] Caspase-9 binds DCC:DIP13alpha complex [Homo sapiens]
releaseDate	2006-08-02
reviewed	[InstanceEdit:204051] Ranganathan, S, 2007-11-23 00:10:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358998] R-HSA-201611.4
summation	[Summation:212559] Caspase-3-mediated cleavage of ROCK I induces MLC phosphoryl...
(hasEvent)	[Pathway:111465] Apoptotic cleavage of cellular proteins [Homo sapiens]
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No pathways have been reviewed or authored by Caspase-mediated cleavage of Rock-1 (201611)