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Details on Person Caspase-mediated cleavage of alpha adducin

Class:Id	Reaction:201608
_displayName	Caspase-mediated cleavage of alpha adducin
_doRelease	TRUE
_timestamp	2017-11-17 22:10:46
authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201610] Matthews, L, 2007-09-03 08:36:41
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:201989] Matthews, L, 2007-10-09 13:44:38 [InstanceEdit:202801] Matthews, L, 2007-11-11 23:40:56
input	[EntityWithAccessionedSequence:201623] ADD1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:202851] Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells
modified	[InstanceEdit:202894] Matthews, L, 2007-11-12 10:01:45 [InstanceEdit:202979] Matthews, L, 2007-11-12 13:46:30 [InstanceEdit:204067] Matthews, L, 2007-11-23 00:38:34 [InstanceEdit:204375] Gopinathrao, G, 2007-11-28 14:04:53 [InstanceEdit:204386] Gopinathrao, G, 2007-11-28 14:37:35 [InstanceEdit:352491] Matthews, L, 2008-06-03 01:13:58 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9029449] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-mediated cleavage of alpha adducin
output	[EntityWithAccessionedSequence:202891] ADD1(1-633) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202890] ADD1(634-737) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:114252] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens] [Reaction:114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 [Homo sapiens] [Reaction:114306] SMAC binds XIAP:Caspase-3 [Homo sapiens] [Reaction:418845] Activation of caspase-3 [Homo sapiens] [Reaction:373700] Caspase-9 binds DCC:DIP13alpha complex [Homo sapiens]
releaseDate	2006-01-23
reviewed	[InstanceEdit:204051] Ranganathan, S, 2007-11-23 00:10:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358841] R-HSA-201608.4
summation	[Summation:202889] The cortical actin cytoskeletal network is lost during apopt...
(hasEvent)	[Pathway:264870] Caspase-mediated cleavage of cytoskeletal proteins [Homo sapiens]
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No pathways have been reviewed or authored by Caspase-mediated cleavage of alpha adducin (201608)