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Details on Person ALK autophosphorylation

Class:IdReaction:201521
_displayNameALK autophosphorylation
_doReleaseTRUE
_timestamp2023-11-09 18:36:25
authored[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
catalystActivity[CatalystActivity:9700102] protein tyrosine kinase activity of ligand-bound ALK dimer [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
edited[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[CandidateSet:9850908] ligand-bound ALK dimer [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:9699630] Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway
[LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
[LiteratureReference:9699636] Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation
[LiteratureReference:9699668] Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain
[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition
[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
[LiteratureReference:9699789] Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity
[LiteratureReference:9699645] Characterization of some molecular mechanisms governing autoactivation of the catalytic domain of the anaplastic lymphoma kinase
[LiteratureReference:9699717] Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
[LiteratureReference:9699620] ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
[LiteratureReference:9667905] Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
modified[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9700208] Rothfels, Karen, 2020-09-14
[InstanceEdit:9700676] Rothfels, Karen, 2020-09-16
[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30
[InstanceEdit:9729893] Rothfels, Karen, 2021-05-04
[InstanceEdit:9730936] Jassal, Bijay, 2021-05-12
[InstanceEdit:9731178] Rothfels, Karen, 2021-05-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
[InstanceEdit:9853039] Rothfels, Karen, 2023-11-09
nameALK autophosphorylation
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[CandidateSet:9850879] Active ALK dimer [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[NegativeRegulation:9700650] Negative regulation by 'ALK dimer:ligand:type I ALK binding TKI [plasma membrane]'
releaseDate2021-06-09
reviewed[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8906586] R-HSA-201521.3
structureModified[InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
summation[Summation:9700129] ALK1 is phosphorylated on tyrosine residues in intracellular...
(hasEvent)[Pathway:201556] Signaling by ALK [Homo sapiens]
(normalReaction)[Reaction:9700181] Autophosphorylation of ALK fusions [Homo sapiens]
[Reaction:9700186] Autophosphorylation of point mutants of ALK [Homo sapiens]
(precedingEvent)[BlackBoxEvent:201515] Active ALK recruits PI3K [Homo sapiens]
[Reaction:9700142] Active ALK binds FRS2 [Homo sapiens]
[Reaction:9700149] Active ALK binds PLCG1 [Homo sapiens]
[Reaction:9700154] Active ALK binds SHC1 [Homo sapiens]
[Reaction:9700156] Active ALK dimer binds IRS1 [Homo sapiens]
[Reaction:9700200] PTPRZ dephosphorylates ligand-bound ALK dimers [Homo sapiens]
[Reaction:9700648] Active ALK binds SRC [Homo sapiens]
[Reaction:9701485] Active ALK binds JAK3 [Homo sapiens]
[BlackBoxEvent:9701524] STAT3 is phosphorylated downstream of active ALK [Homo sapiens]
(updatedInstance)[_UpdateTracker:9853225] Update Tracker - [Reaction:201521] ALK autophosphorylation - v87:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by ALK autophosphorylation (201521)
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