Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PI3K synthesizes PIP3 downstream of ALK

Class:Id	Reaction:201510
_displayName	PI3K synthesizes PIP3 downstream of ALK
_doRelease	TRUE
_timestamp	2021-05-14 15:25:50
authored	[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
catalystActivity	[CatalystActivity:9700106] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Active ALK:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
edited	[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
literatureReference	[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway [LiteratureReference:201541] Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis [LiteratureReference:9699732] NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner [LiteratureReference:9699730] NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a [LiteratureReference:9700372] Oncogenic mutations of ALK kinase in neuroblastoma [LiteratureReference:9699725] Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma [LiteratureReference:9699745] Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9700213] Rothfels, Karen, 2020-09-14 [InstanceEdit:9700676] Rothfels, Karen, 2020-09-16 [InstanceEdit:9712099] Rothfels, Karen, 2021-01-14 [InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9730936] Jassal, Bijay, 2021-05-12 [InstanceEdit:9731182] Rothfels, Karen, 2021-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3K synthesizes PIP3 downstream of ALK
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:201515] Active ALK recruits PI3K [Homo sapiens] [Reaction:201521] ALK autophosphorylation [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8899222] R-HSA-201510.2
summation	[Summation:9700203] PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK...
(hasEvent)	[Pathway:201556] Signaling by ALK [Homo sapiens]
(normalReaction)	[Reaction:9712084] PI3K synthesizes PIP3 downstream of ALK mutants [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853188] Update Tracker - [Reaction:201510] PI3K synthesizes PIP3 downstream of ALK - v87:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by PI3K synthesizes PIP3 downstream of ALK (201510)