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Details on Person Activated type I receptor phosphorylates R-Smad1/5/8 directly

Class:Id	Reaction:201476
_displayName	Activated type I receptor phosphorylates R-Smad1/5/8 directly
_doRelease	TRUE
_timestamp	2019-02-25 18:23:23
authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
catalystActivity	[CatalystActivity:201437] transmembrane receptor protein serine/threonine kinase activity of BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
input	[Complex:201477] BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:202605] The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase [LiteratureReference:202620] MADR1, a MAD-related protein that functions in BMP2 signaling pathways
modified	[InstanceEdit:202635] Jassal, B, 2007-11-07 13:11:04 [InstanceEdit:203121] Jassal, B, 2007-11-12 14:50:39 [InstanceEdit:203414] Jassal, B, 2007-11-13 09:46:28 [InstanceEdit:203528] Jassal, B, 2007-11-14 09:47:03 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9638136] D'Eustachio, Peter, 2019-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated type I receptor phosphorylates R-Smad1/5/8 directly
output	[Complex:201467] BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:201648] An anchoring protein, Endofin, recruits R-Smad1/5/8 [Homo sapiens] [Reaction:201443] Type II receptor phosphorylates type I receptor [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9635710] Mi, Huaiyu, 2019-02-07
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360802] R-HSA-201476.4
summation	[Summation:176013] Activated type I receptor kinase directly phosphorylates two...
(hasEvent)	[Pathway:201451] Signaling by BMP [Homo sapiens]
(precedingEvent)	[Reaction:201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777089] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v72:[modifyText] [_UpdateTracker:9788948] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v39:[modifyText] [_UpdateTracker:9789112] Update Tracker - [Reaction:201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - v38:[modifyText]
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